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Abstract
A novel processing technique is reported to construct three-dimensional biodegradable
polymer foams with precise anatomical shapes. The technique involved the lamination
of highly-porous membranes of porosities up to 90%. Implants with specific shapes
were prepared made of poly(L-lactic acid) and copolymers of poly(DL-lactic-co-glycolic
acid) to evaluate feasibility. The biomaterials produced have pore morphologies similar
to those of the constituent membranes. The pores of adjacent layers of laminated devices
are interconnected, resulting in continuous pore structures. The compressive creep
behaviour of multilayered devices is also similar to that of the individual layers.
Recent discoveries from our group and others that organs and tissues can be regenerated
and reconstructed, using cells cultured on synthetic biodegradable polymers, renders
this method useful in creating polymer-cell graft for use in cell transplantation.