• Record: found
  • Abstract: found
  • Article: not found

Radiosensitivity testing of human primary brain tumor specimens.

International Journal of Radiation Oncology, Biology, Physics

Astrocytoma, pathology, Brain Neoplasms, Cell Survival, radiation effects, Glioblastoma, Glutathione, analysis, Humans, In Vitro Techniques, Oligodendroglioma, Radiation Tolerance, Tumor Cells, Cultured, Tumor Stem Cell Assay

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


      The inherent radiosensitivity of early passage cells derived from 22 patients with tumors of glial origin has been determined using a clonogenic assay system. The mean (+/- SD) surviving fraction at 2 Gy was 0.37 +/- 0.22 (range = 0.02-0.87). No correlation between inherent radiosensitivity and tumor cell plating efficiency or intracellular glutathione was observed. Tumor cells that were both resistant to nitrosoureas and expressed the Mer+ phenotype did not differ significantly in their radiosensitivity as compared to cells that were repair deficient (Mer-) and sensitive to nitrosoureas. Initial clinical follow-up suggests that factors in addition to inherent tumor cell radiosensitivity, such as performance status and age, continue to be the most important determinants of the response of patients with primary brain tumors to radiotherapy.

      Related collections

      Author and article information



      Comment on this article