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      Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development

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      Mechanisms of Development

      Elsevier BV

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          Abstract

          Unlike gap genes in the trunk region of Drosophila embryos, gap genes in the head were presumed not to regulate each other's transcription. Here, we show that in tailless (tll) loss-of-function mutants the empty spiracles (ems) expression domain in the head expands, whereas it retracts in tll gain-of-function embryos. We have identified a 304bp element in the ems-enhancer which is sufficient to drive expression in the head and brain and which contains two TLL and two BCD binding sites. Transgenic reporter gene lines containing mutations of the TLL binding sites demonstrate that tll directly inhibits the expression of ems in the early embryonic head and the protocerebral brain anlage. These results are the first demonstration of direct transcriptional regulation between gap genes in the head.

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          Author and article information

          Journal
          Mechanisms of Development
          Mechanisms of Development
          Elsevier BV
          09254773
          December 2001
          December 2001
          : 109
          : 2
          : 161-172
          Article
          10.1016/S0925-4773(01)00519-6
          11731230
          © 2001

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