Lipid Formulations of Polyene Antifungal Drugs and Attenuation of Associated Nephrotoxicity

Abstract

Amphotericin B is an effective broad-spectrum antifungal agent, but various side effects, especially nephrotoxicity, have restricted its use. Recently, lipid formulations of amphotericin B have been developed in order to reduce its toxic side effects. Clinical trials, although in the early stages, suggest promising results, and that some of these lipid formulations are potent and less toxic, even at higher doses. We summarize herein the existing information about newer lipid formulations of polyene antifungal drugs, which could attenuate associated nephrotoxicity.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2001

Publication date (Print): 2001

Publication date (Electronic): 10 October 2001

Volume: 89

Issue: 3

Pages: 251-254

Affiliations

^aDepartment of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Mass., USA; ^bSecond Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan; ^cCenter for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA and ^dDepartment of Medicine, Penn State College of Medicine, Hershey, Pa., USA

Article

Publisher ID: 46081 Other ID: Nephron 2001;89:251–254

DOI: 10.1159/000046081

PubMed ID: 11598385

Copyright statement: © 2001 S. Karger AG, Basel

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Page count

References: 21, Pages: 4

Product

Self URI (application/pdf): https://www.karger.com/Article/Pdf/46081

Self URI (text/html): https://www.karger.com/Article/FullText/46081

Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology

Categories

Subject: Short Review