Gastric heterotopic pancreas and stromal tumors smaller than 3 cm in diameter: clinical and computed tomography findings

Abstract

Background

Identifying gastric heterotopic pancreas and stromal tumors is difficult. Few studies have reported computed tomography (CT) findings for differentiating lesions less than 3 cm in diameter. In this study, we aimed to identify clinical characteristics and CT findings that can differentiate gastric heterotopic pancreatic lesions from stromal tumors less than 3 cm in diameter.

Methods

A total of 132 patients with pathologically confirmed gastric heterotopic pancreas ( n = 66) and stromal tumors ( n = 66) were included. Each group was divided into primary ( n = 50) and validation cohort ( n = 16). Clinical characteristics and CT findings were retrospectively reviewed. CT findings included location, border, contour, growth pattern, enhancement pattern and grade, the enhancement value of tumor, enhancement ratio of tumor, and enhancement ratio of tumor to pancreas in venous phase. The findings in the two groups were compared using the Pearson χ ² test or Student t-test. Receiver operating characteristic curves were used to determine areas under the curve and optimal cut-offs.

Results

Significant differences were observed between heterotopic pancreas and stromal tumors in the distribution of tumor location, border, contour (all P < 0.001), enhancement values ( P < 0.001), enhancement ratios of tumors ( P < 0.001), and enhancement ratios of tumors to pancreas ( P < 0.001). No significant differences existed in growth pattern ( P = 0.203). The area under the curve differed significantly between enhancement ratio of tumor to pancreas and enhancement ratio ( P = 0.030). There were significant differences in above characteristics between two groups in validation cohort.

Conclusions

Heterotopic pancreas has characteristic CT features differentiating it from stromal tumors.