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Lack of ultrastructural detrusor changes following endoscopic injection of botulinum toxin type a in overactive neurogenic bladder.
A Haferkamp
1 ,
B Schurch ,
A Reitz ,
U Krengel ,
J Grosse ,
G Kramer ,
S Schumacher ,
P J Bastian ,
R Büttner ,
S C Müller ,
M Stöhrer
Dec 2004
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Abstract
Endoscopical injections of Botulinum toxin type A into the detrusor muscle are gaining clinical acceptance in the treatment of neurogenic detrusor overactivity. Structural effects of Botulinum toxin type A are only known from studies on striated muscles, where a widespread nerve sprouting occurs temporarily. The aim of this study was to evaluate the ultrastructural effects of Botulinum toxin type A injections on the human detrusor.