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      Dinucleotide relative abundance extremes: a genomic signature.

      1 ,
      Trends in genetics : TIG
      Elsevier BV

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          Abstract

          Early biochemical experiments established that the set of dinucleotide odds ratios or 'general design' is a remarkably stable property of the DNA of an organism, which is essentially the same in protein-coding DNA, bulk genomic DNA, and in different renaturation rate and density gradient fractions of genomic DNA in many organisms. Analysis of currently available genomic sequence data has extended these earlier results, showing that the general designs of disjoint samples of a genome are substantially more similar to each other than to those of sequences from other organisms and that closely related organisms have similar general designs. From this perspective, the set of dinucleotide odds ratio (relative abundance) values constitute a signature of each DNA genome, which can discriminate between sequences from different organisms. Dinucleotide-odds ratio values appear to reflect not only the chemistry of dinucleotide stacking energies and base-step conformational preferences, but also the species-specific properties of DNA modification, replication and repair mechanisms.

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          Author and article information

          Journal
          Trends Genet
          Trends in genetics : TIG
          Elsevier BV
          0168-9525
          0168-9525
          Jul 1995
          : 11
          : 7
          Affiliations
          [1 ] Department of Mathematics, Stanford University, CA 94305-2125, USA.
          Article
          S0168952500890769
          10.1016/s0168-9525(00)89076-9
          7482779
          9be5062f-149f-49fd-9542-ac83918cb501
          History

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