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      Proteinuria and Renal Tubular Damage: Urinary N-Acetyl- β-D-Glucosaminidase and Isoenzymes in Dissimilar Renal Disease

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          Markers of renal tubular injury are difficult to interpret in patients with proteinura. The 24-hour urinary N-acetyl-β- D-glucosaminidase (NAG) concentration was measured in 167 patients with dissimilar renal disease, function, and proteinuria. NAG isoenzymes were also separated in 69 patients, using a modified fast protein liquid chromatography technique. The ‘A2’ isoenzyme predominated at all levels of renal function and in all diagnostic groups. Urinary NAG and proteinuria were well correlated at all levels of renal function, as was NAG ‘A2’ isoenzyme. Proteinuria and urinary NAG were similarly correlated in patients with different glomerulonephritides, hypertensive nephrosclerosis, and chronic pyelonephritis, but not in those with diabetic nephropathy.

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          Presence of serum and tissue forms of N-acetyl-β-glucosaminidase in urine from patients with renal disease

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            Urinary excretion of β-hexosaminidase in different forms of proteinuria


              Author and article information

              Am J Nephrol
              American Journal of Nephrology
              S. Karger AG
              June 1998
              06 May 1998
              : 18
              : 3
              : 179-185
              a Regional Renal Unit and b Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UK
              13334 Am J Nephrol 1998;18:179–185
              © 1998 S. Karger AG, Basel

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              Page count
              Figures: 6, Tables: 3, References: 24, Pages: 7
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/13334
              Clinical Study


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