Contributors
Qin Huang: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Ken Y. Chan: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Isabelle G. Tobey: Role: InvestigationRole: Writing – review & editing
Yujia Alina Chan: Role: ConceptualizationRole: Writing – original draft
Tim Poterba: Role: InvestigationRole: SoftwareRole: Writing – review & editing
Christine L. Boutros: Role: Investigation
Alejandro B. Balazs: Role: InvestigationRole: Resources
Richard Daneman:
ORCID: http://orcid.org/0000-0002-7749-6353
Role: ResourcesRole: Writing – review & editing
Jonathan M. Bloom:
ORCID: http://orcid.org/0000-0001-8497-1434
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Cotton Seed: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Benjamin E. Deverman:
ORCID: http://orcid.org/0000-0002-6223-9303
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Giovanni Di Pasquale: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
14
November
2019
Publication date Collection: 2019
Volume: 14
Issue: 11
Electronic Location Identifier: e0225206
Affiliations
[1
]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge,
MA, United States of America
[2
]
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States of America
[3
]
Departments of Neurosciences and Pharmacology, University of California, San Diego,
La Jolla, CA, United States of America
[4
]
Department of Pharmacology, University of California, San Diego, La Jolla, CA, United
States of America
National Institutes of Health, UNITED STATES
Author notes
Competing Interests: B.D. and K.C. are inventors on patents related to the AAV-PHP.B vectors filed by the
California Institute of Technology; a provisional patent application related to this
work controlled by the Broad Institute has been filed; B.D. is a consultant for Voyager
Therapeutics and a member of the Scientific Advisory Board for Tevard Therapeutics.
All other authors declare no competing interests. This does not alter our adherence
to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-19-24154
DOI: 10.1371/journal.pone.0225206
PMC ID: 6855452
PubMed ID: 31725765
SO-VID: 9d44f8e1-9245-4e55-8b54-73f3217832d3
Copyright © © 2019 Huang et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 26
August
2019
Date
accepted
: 29
October
2019
Page count
Figures: 4,
Tables: 0,
Pages: 17
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100013113, Stanley Center for Psychiatric Research, Broad Institute;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6223-9303
Benjamin E. Deverman
Funded by: funder-id http://dx.doi.org/10.13039/100000065, National Institute of Neurological Disorders and Stroke;
Award ID: UG3NS111689
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6223-9303
Benjamin E. Deverman
This study was supported by the Stanley Foundation and Stanley Center for Psychiatric
Research and by the National Institute Of Neurological Disorders and Stroke of the
National Institutes of Health under Award Number UG3NS111689. The funders had no role
in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Structure
Subject:
Capsids
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Animal Genomics
Subject:
Mammalian Genomics
Subject:
Research and Analysis Methods
Subject:
Histochemistry and Cytochemistry Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunohistochemistry Techniques
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Physiology
Subject:
Cell Binding
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Galactose
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Carbohydrates
Subject:
Monosaccharides
Subject:
Galactose
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Research and Analysis Methods
Subject:
Chemical Characterization
Subject:
Binding Analysis
Subject:
Cell Binding Assay
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