To evaluate the results of laser in situ keratomileusis (LASIK) and IntraLASIK in the treatment of myopic patients with nystagmus. Eight patients with congenital nystagmus (16 eyes), aged 23 to 49 years, had LASIK surgery. Corneal flaps were created using the Bausch & Lomb Hansatome microkeratome or the IntraLase femtosecond laser. The ablations were performed with the Bausch & Lomb excimer laser with an active tracking system. In some patients, the eyes were fixated with forceps or a fixation ring during laser ablation. The refractive errors were corrected in all cases. There was no decentration or loss of best corrected visual acuity greater than 1 line. In 56% of the eyes, the postoperative uncorrected visual acuity was better than the best spectacle-corrected visual acuity (BSCVA). The BSCVA improved in 62.5% of the eyes. The overall visual performance improved in all patients. One patient who did not drive before surgery became eligible for a driver's license after surgery. Selected patients with myopia and congenital nystagmus may benefit from laser refractive surgery. Laser refractive surgery may be safely and accurately performed using the Hansatome microkeratome or the IntraLase femtosecond laser and an active tracking system with or without mechanical fixation. The BSCVA may improve in certain patients postoperatively.