Michael Wainberg:
ORCID: https://orcid.org/0000-0001-6061-0239
Role: ConceptualizationRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Samuel E. Jones:
ORCID: https://orcid.org/0000-0003-0153-922X
Role: InvestigationRole: Writing – review & editing
Lindsay Melhuish Beaupre:
ORCID: https://orcid.org/0000-0001-8224-1307
Role: InvestigationRole: Writing – review & editing
Sean L. Hill:
ORCID: https://orcid.org/0000-0001-8055-860X
Role: InvestigationRole: Writing – review & editing
Daniel Felsky:
ORCID: https://orcid.org/0000-0003-1831-9848
Role: InvestigationRole: Writing – review & editing
Manuel A. Rivas:
ORCID: https://orcid.org/0000-0003-1457-9925
Role: InvestigationRole: Writing – review & editing
Andrew S. P. Lim:
ORCID: https://orcid.org/0000-0003-2179-1553
Role: InvestigationRole: Writing – review & editing
Hanna M. Ollila:
ORCID: https://orcid.org/0000-0002-5302-6429
Role: InvestigationRole: Writing – review & editing
Shreejoy J. Tripathy:
ORCID: https://orcid.org/0000-0002-1007-9061
Role: ConceptualizationRole: InvestigationRole: SupervisionRole: Writing – review
& editing
Vikram Patel: Role: Academic Editor
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
12
October
2021
Publication date Collection:
October
2021
Volume: 18
Issue: 10
Electronic Location Identifier: e1003782
Affiliations
[1
]
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto,
Canada
[2
]
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki,
Finland
[3
]
University of Exeter Medical School, Exeter, United Kingdom
[4
]
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental
Health, Toronto, Canada
[5
]
Institute of Medical Sciences, University of Toronto, Toronto, Canada
[6
]
Department of Psychiatry, University of Toronto, Toronto, Canada
[7
]
Department of Physiology, University of Toronto, Toronto, Canada
[8
]
Biostatistics Division, Dalla Lana School of Public Health, University of Toronto,
Toronto, Canada
[9
]
Department of Genetics, Stanford University, Stanford, California, United States of
America
[10
]
Sunnybrook Health Sciences Centre, Toronto, Canada
[11
]
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
[12
]
Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts,
United States of America
[13
]
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts,
United States of America
[14
]
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
and Harvard Medical School, Boston, Massachusetts, USA
Harvard Medical School, UNITED STATES
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: M.A.R. is on the SAB of 54Gene, Related Sciences and scientific
founder of Broadwing Bio and has advised BioMarin, Third Rock Ventures and MazeTx;
the remaining authors declare no competing interests.
Author information
Article
Publisher ID:
PMEDICINE-D-21-02038
DOI: 10.1371/journal.pmed.1003782
PMC ID: 8509859
PubMed ID: 34637446
SO-VID: 9e962161-e94b-45e7-bbe2-3f8bb350bdcc
Copyright © © 2021 Wainberg et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100001201, kavli foundation;
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
funder-id http://dx.doi.org/10.13039/501100004089, krembil foundation;
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
camh discovery fund
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
mclaughlin foundation
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
nserc
Award ID: RGPIN-2020-05834
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
nserc
Award ID: DGECR-2020-00048
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
cihr
Award ID: NGN-171423
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1007-9061
Shreejoy J. Tripathy
Funded by:
michael and sonja koerner foundation new scientist program
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1831-9848
Daniel Felsky
Funded by:
funder-id http://dx.doi.org/10.13039/501100004089, krembil foundation;
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1831-9848
Daniel Felsky
Funded by:
camh discovery fund
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1831-9848
Daniel Felsky
Funded by:
mclaughlin foundation
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1831-9848
Daniel Felsky
The authors acknowledge Milos Milic for data curation assistance. MW and SJT acknowledge
support from the Kavli Foundation, Krembil Foundation, CAMH Discovery Fund, the McLaughlin
Foundation, NSERC (RGPIN-2020-05834 and DGECR-2020-00048) and CIHR (NGN-171423). DF
is supported by the Michael and Sonja Koerner Foundation New Scientist Program, Krembil
Foundation, CAMH Discovery Fund, and the McLaughlin Foundation. The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript. This research was conducted under the auspices of UK Biobank application
61530, “Multimodal subtyping of mental illness across the adult lifespan through integration
of multi-scale whole-person phenotypes”.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Physiology
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Physiological Processes
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Sleep
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Medicine and Health Sciences
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Epidemiology
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Medical Risk Factors
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Mood Disorders
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Depression
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Medicine and Health Sciences
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Health Care
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Patients
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Inpatients
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Schizophrenia
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Mood Disorders
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Bipolar Disorder
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Neuropsychiatric Disorders
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Anxiety Disorders
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Neuroses
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Anxiety Disorders
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Medicine and Health Sciences
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Mental Health and Psychiatry