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      Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking.

      1 ,
      Small (Weinheim an der Bergstrasse, Germany)

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          Abstract

          Nanoparticles have many potential applications in tumor therapy. Systemically administered nanoparticles should remain in circulation for a long time to increase their accumulation in targeted tissues before being cleared by the reticuloendothelial system, and be effectively internalized by the targeted cells, which can be influenced significantly by the physicochemical characteristics of nanoparticles, such as particle size, surface properties, and particle shape. This review highlights the impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells.

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          Author and article information

          Journal
          Small
          Small (Weinheim an der Bergstrasse, Germany)
          1613-6829
          1613-6810
          May 27 2013
          : 9
          : 9-10
          Affiliations
          [1 ] Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
          Article
          10.1002/smll.201201390
          23019091
          9eaac1ba-6107-4880-adc5-4e6293286622
          Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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