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      How to Make More Published Research True

      research-article
      Author(s): 1 , 2 , 3 , 4 , *
      Publication date (Electronic):
      Journal: PLoS Medicine
      Publisher: Public Library of Science

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In a 2005 paper that has been accessed more than a million times, John Ioannidis explained why most published research findings were false. Here he revisits the topic, this time to address how to improve matters.

          Please see later in the article for the Editors' Summary

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          A call for transparent reporting to optimize the predictive value of preclinical research.

          Story C Landis, Susan Amara, Khusru Asadullah … (2012)
          The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.
          Article 0 comments Cited 446 times – based on 0 reviews     Review now
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            Scientific method: statistical errors.

            Regina Nuzzo, Vania Estrela (2014)
            Article 0 comments Cited 411 times – based on 0 reviews     Review now
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              Reproducible research in computational science.

              Roger Peng (2011)
              Computational science has led to exciting new developments, but the nature of the work has exposed limitations in our ability to evaluate published findings. Reproducibility has the potential to serve as a minimum standard for judging scientific claims when full independent replication of a study is not possible.
              Article 0 comments Cited 396 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PLoS Med
                Journal ID (iso-abbrev): PLoS Med
                Journal ID (publisher-id): PLoS
                Journal ID (pmc): plosmed
                Title: PLoS Medicine
                Publisher: Public Library of Science (San Francisco, USA )
                ISSN (Print): 1549-1277
                ISSN (Electronic): 1549-1676
                Publication date Collection: October 2014
                Publication date (Electronic): 21 October 2014
                Volume: 11
                Issue: 10
                Electronic Location Identifier: e1001747
                Affiliations
                [1 ]Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, United States of America
                [2 ]Department of Medicine, Stanford Prevention Research Center, Stanford, California, United States of America
                [3 ]Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America
                [4 ]Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, California, United States of America
                Author notes

                JPAI is a member of the Editorial Board of PLOS Medicine. The author has declared that no competing interests exist.

                Wrote the first draft of the manuscript: JPAI. Wrote the paper: JPAI. ICMJE criteria for authorship read and met: JPAI. Conceived the ideas and concepts discussed: JPAI.

                Article
                Publisher ID: PMEDICINE-D-14-01145
                DOI: 10.1371/journal.pmed.1001747
                PMC ID: 4204808
                PubMed ID: 25334033
                SO-VID: 9ed695f9-c630-4958-804e-55e7956c9f50
                Copyright statement: Copyright @ 2014
                License:

                A. Ioannidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Page count
                Pages: 6
                Funding
                The Meta-Research Innovation Center at Stanford is funded by the Laura and John Arnold Foundation. The funders had no role in the decision to publish or in the preparation of the manuscript.
                Categories
                Subject: Essay
                Subject: Medicine and Health Sciences

                ScienceOpen disciplines: Medicine
                Data availability:
                ScienceOpen disciplines: Medicine

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