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Conformational disease
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Abstract
Several diverse disorders, including the prevalent dementias and encephalopathies,
are now believed to arise from the same general disease mechanism. In each, there
is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation
of these aggregates and the acceleration of their formation by stress explain the
characteristic late or episodic onset of the clinical disease. The understanding of
these processes at the molecular level is opening prospects of more rational approaches
to investigation and therapy.