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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
Amar Gajjar
1 ,
Murali Chintagumpala ,
David Ashley ,
Stewart Kellie ,
Larry E Kun ,
Thomas E Merchant ,
Shaio Woo ,
Greg Wheeler ,
Valerie Ahern ,
Matthew J Krasin ,
Maryam Fouladi ,
Alberto Broniscer ,
Robert Krance ,
Gregory A Hale ,
Clinton F Stewart ,
Robert Dauser ,
Robert A Sanford ,
Christine Fuller ,
Ching Lau ,
James M Boyett ,
Dana Wallace ,
Richard J Gilbertson
Oct 2006
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Abstract
Current treatment for medulloblastoma, which includes postoperative radiotherapy and 1 year of chemotherapy, does not cure many children with high-risk disease. We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma.