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Ocular tolerance of preservatives and alternatives
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Abstract
Eye drops are multiple dosage forms protected against microbial contamination by means
of preservatives. However, the ocular tolerance of these chemicals can vary and this
may result in adverse toxic or allergic reactions. This overview presents the pharmacopoeial
requirements for the preservation of eye drops, the factors affecting ocular tolerance
as well as the adverse external ocular effects induced by preservatives. The alternatives
to the use of preservatives are also discussed, including the recent progress in eye
drops packaging.