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Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research
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Abstract
The specific properties of fluorocarbons, exceptional chemical and biological inertness,
high gas-dissolving capacity, low surface tension, excellent spreading characteristics
and high fluidity, have triggered numerous applications of these compounds in oxygen
delivery. An injectable emulsion of fluorocarbon-in-water destined to deliver oxygen
to tissues at risk of hypoxia has now completed Phase III clinical trials in Europe.
A neat fluorocarbon is currently investigated in Phase II for treatment of acute respiratory
failure by liquid ventilation. Fluorinated lipids and fluorinated surfactants can
be used to elaborate and stabilize various colloidal systems, including different
types of emulsions, vesicles and tubules, that also show promise for controlled release
drug delivery.