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      NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.

      Cancer Cell

      Adenocarcinoma, genetics, pathology, Animals, Cell Survival, Homeodomain Proteins, physiology, Humans, Lung, embryology, Lung Neoplasms, Mice, Mice, Transgenic, Nuclear Proteins, Transcription Factors

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          Abstract

          Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas. In T cell acute lymphoblastic leukemia, gene rearrangements lead to aberrant expression of NKX2-1/TTF-1. Despite accumulating evidence supporting its oncogenic role, it has become apparent that NKX2-1/TTF-1 expression also has biological and clinical functions in the opposite direction that act against tumor progression. Herein, we review recent findings showing these enigmatic double-edged characteristics, with special attention given to the roles of NKX2-1/TTF-1 in lung development and carcinogenesis. Copyright © 2013 Elsevier Inc. All rights reserved.

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          Journal
          23763999
          10.1016/j.ccr.2013.04.002

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