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      Red Cell Distribution Width: A Predictor of All-Cause Mortality in Patients with Coronary Artery Disease

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          Impact of Red Blood Cell Distribution Width on Long-Term Mortality in Patients with ST-Elevation Myocardial Infarction

          Objectives: Recent studies have reported increased red blood cell distribution width (RDW) has been associated with adverse outcomes in heart failure and stable coronary disease. We investigated the association between RDW and risk of all-cause mortality in patients with ST-elevation myocardial infarction (STEMI) who were free of heart failure at baseline. Methods: We enrolled 691 patients with STEMI who were free of heart failure at baseline confirmed by coronary angiography in Beijing Friendship Hospital from January 2007 to December 2008. According to the median RDW at baseline (13.0%) on admission, the patients were divided into two groups: a low-RDW group (RDW <13.0%, n = 329) and a high-RDW group (RDW ≥13.0%, n = 362). All-cause mortality rates were compared between groups. Mean duration of follow-up was 41.8 months. The relation between RDW and clinical outcomes after hospital discharge were tested using Cox regression models, adjusting for clinical variables. At the same time, the sensitivity and specificity of RDW were analyzed by ROC analysis. Results: Forty-seven patients (6.8%) died during follow-up. The cumulative incidence of all-cause death was significantly higher in the high-RDW group than in the low-RDW group (log-rank p = 0.007). Multivariate analysis revealed that high RDW was associated with all-cause mortality (hazard ratio: 3.43; 95% confidence interval: 1.17-8.32; p = 0.025). The area under the ROC curve was 0.562. Conclusion: From the statistical point of view, increased RDW is associated with all-cause and cardiac mortality rates in patients with STEMI who were free of heart failure at baseline. But RDW is a marker with a very low prognostic accuracy that does not seem to be clinically helpful.
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            Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock.

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              Red cell distribution width is a predictor of mortality in patients undergoing coronary artery bypass surgery.

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                Author and article information

                Journal
                CRD
                Cardiology
                10.1159/issn.0008-6312
                Cardiology
                S. Karger AG
                0008-6312
                1421-9751
                2015
                January 2015
                03 December 2014
                : 130
                : 1
                : 23-24
                Affiliations
                aDepartment of Cardiology, EskiQehir Military Hospital, EskiQehir, bDepartment of Cardiology, Etimesgut Military Hospital, and cDepartment of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey
                Author notes
                *Dr. Sevket Balta, Department of Cardiology, Eskişehir Military Hospital , Vişnelik Mah., Atatürk Caddesi, TR-26020 Akarbaşı/Eskişehir (Turkey), E-Mail drsevketb@gmail.com
                Article
                368393 Cardiology 2015;130:23-24
                10.1159/000368393
                25471310
                a2554984-8eed-4ad3-bcfe-541b8481c4f3
                © 2012 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                : 16 September 2014
                : 16 September 2014
                Page count
                Pages: 2
                Categories
                Letter to the Editor

                General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
                Acute myocardial infarction,Inflammation,Acute coronary syndrome

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