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      Sarcopenia and Visceral Adiposity Are Not Independent Prognostic Markers for Extensive Disease of Small-Cell Lung Cancer: A Single-Centered Retrospective Cohort Study

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          Abstract

          Background

          Sarcopenia and visceral adiposity have been suggested to affect prognosis and treatment efficacy in various types of cancers. The aim of our study was to evaluate whether pretreatment sarcopenia and visceral adiposity are associated with prognosis in patients with extensive-disease small-cell lung cancer (ED-SCLC).

          Methods

          Between September 2007 and March 2018, 128 ED-SCLC patients received first-line and platinum-based chemotherapy at our hospital. Based on pretreatment body mass index (BMI), psoas muscle index (PMI), intramuscular adipose tissue content (IMAC) and visceral-to-subcutaneous fat ratio (VSR) at lumbar vertebra L3 level, we divided these patients into two groups, and then compared overall survival (OS) and progression-free survival (PFS). Adjusted by age, serum albumin, lactate dehydrogenase (LDH), clinical stage and performance status, we detected independent prognostic factors by multivariate Cox proportional hazard analyses.

          Results

          We did not find any significant differences in OS and PFS between two groups divided by BMI, PMI, IMAC and VSR. According to multivariate analyses, none of BMI, PMI, IMAC and VSR was an independent prognostic factor of OS and PFS.

          Conclusions

          Neither pretreatment sarcopenia nor visceral adiposity is a prognostic marker of patients with ED-SCLC treated with standard regimen of platinum-based chemotherapy.

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          Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults.

          Yuhei Hamaguchi, Toshimi Kaido, Shinya Okumura … (2016)
          Low skeletal muscle, referred to as sarcopenia, has been shown to be an independent predictor of lower overall survival in various kinds of diseases. Several studies have evaluated the low skeletal muscle mass using computed tomography (CT) imaging. However, the cutoff values based on CT imaging remain undetermined in Asian populations.
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            Prevalence and predictive value of pre-therapeutic sarcopenia in cancer patients: A systematic review

            Frederic Pamoukdjian, Thierry Bouillet, Vincent Levy … (2018)
            Article 0 comments Cited 111 times – based on 0 reviews     Review now
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              The revised TNM staging system for lung cancer.

              Thomas Crowley, Ramón Rami-Porta, P Goldstraw (2009)
              The International Staging Committee (ISC) of the International Association for the Study of Lung Cancer (IASLC) collected 68,463 patients with nonsmall cell lung cancer and 13,032 patients with small cell lung cancer, registered or diagnosed from 1990 to 2000, whose records had adequate information for analyzing the tumor, node, metastasis (TNM) classification. The T, N, and M descriptors were analyzed, and recommendations for changes in the seventh edition of the TNM classification were proposed based on differences in survival. For the T component, tumor size was found to have prognostic relevance, and its analysis led to recommendations to subclassify T1 tumors into T1a ( 2 - 3 - 5 - 7 cm into T3. Furthermore, with additional nodules in the same lobe as the primary tumors, T4 tumors would be reclassified as T3; with additional nodules in another ipsilateral lobe, M1 as T4; and with pleural dissemination, T4 as M1. There were no changes in the N category. In the M category, M1 was recommended to be subclassified into M1a (contralateral lung nodules and pleural dissemination) and M1b (distant metastasis). The proposed changes for the new stage grouping were to upstage T2bN0M0 from stage IB to stage IIA, and to downstage T2aN1M0 from stage IIB to stage IIA and T4N0-N1M0 from stage IIIB to stage IIIA. The proposed changes better differentiate tumors of different prognoses.
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                Author and article information

                Journal
                Journal ID (nlm-ta): World J Oncol
                Journal ID (iso-abbrev): World J Oncol
                Journal ID (publisher-id): Elmer Press
                Title: World Journal of Oncology
                Publisher: Elmer Press
                ISSN (Print): 1920-4531
                ISSN (Electronic): 1920-454X
                Publication date (Print): August 2020
                Publication date (Electronic): 10 August 2020
                Volume: 11
                Issue: 4
                Pages: 139-149
                Affiliations
                [a ]Department of Respiratory Medicine, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka 543-0035, Japan
                [b ]Department of Respiratory Medicine, Daini Osaka Police Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka 543-8922, Japan
                Author notes
                [c ]Corresponding Author: Seigo Minami, Department of Respiratory Medicine, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka-City, Osaka 543-0035, Japan. Email: seigominami@ 123456oph.gr.jp
                Article
                DOI: 10.14740/wjon1289
                PMC ID: 7430857
                PubMed ID: 32849954
                SO-VID: a2b57402-1968-44d7-ae9f-0a39cb81f215
                Copyright © Copyright 2020, Minami et al.
                License:

                This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 2 May 2020
                Date accepted : 4 June 2020
                Categories
                Subject: Original Article

                Keywords: sarcopenia,visceral adiposity,extensive disease,small-cell lung cancer,body mass index,psoas muscle index,intramuscular adipose tissue content,visceral-to-subcutaneous adipose tissue area ratio
                Data availability:
                Keywords: sarcopenia, visceral adiposity, extensive disease, small-cell lung cancer, body mass index, psoas muscle index, intramuscular adipose tissue content, visceral-to-subcutaneous adipose tissue area ratio

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