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      Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.

      1 , , , ,
      Lancet (London, England)
      Elsevier BV

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          Abstract

          Ivabradine specifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting other aspects of cardiac function. We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          Sep 06 2008
          : 372
          : 9641
          Affiliations
          [1 ] Royal Brompton Hospital, London, UK.
          Article
          S0140-6736(08)61170-8
          10.1016/S0140-6736(08)61170-8
          18757088
          a34eafbe-44e8-4c58-8862-21e5ff250c02
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