Experimental IgA Nephropathy Induced by a Low-Dose Environmental Mycotoxin, Nivalenol

Abstract

Based on the hypothesis that IgA nephropathy (IgAN) is triggered by some exogenous antigen(s) which induces dysregulation of the mucosal immune system, we developed an experimental model of orally induced IgAN by an environmental mycotoxin, nivalenol (NIV), which often contaminates agricultural products in Southeast Asia and Japan. In the present study, low doses of oral NIV reproducibly induced significant IgA deposits in the glomerular mesangium and elevated serum IgA levels in mice irrespective of the strain; the degree of immunopathological changes analogous to human IgAN was associated with the dose and duration of NIV treatment. Furthermore, a competitive enzyme-linked immunosorbent assay with an NIV analogue-protein conjugate disclosed that the IgA antibody in the sera from the NIV model mice had a higher affinity to the mycotoxin. Conclusively, these findings suggest that NIV induces some pathological changes in mice which resemble those in human IgAN, and that this mycotoxin is associated with pathogenesis in some types of glomerulonephritis.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 19 December 2008

Volume: 75

Issue: 4

Pages: 469-478

Affiliations

^aKidney Center, Toranomon Hospital, ^bOkinaka Memorial Institute for Medical Research, ^cDepartment of Dietetics, Otsuma Women’s College, ^dDepartment of Anatomy, Jikei University School of Medicine, ^eInstitute of Community Medicine, University of Tsukuba, ^fDepartment of Medicine, Tokyo Medical and Dental University, and ^gDepartment of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan

Article

Publisher ID: 189643 Other ID: Nephron 1997;75:469–478

DOI: 10.1159/000189643

PubMed ID: 9127336

Copyright statement: © 1997 S. Karger AG, Basel

License:

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Page count

Pages: 10

Product

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Categories

Subject: Original Paper