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Abstract
Previously, we have reported that incorporation of the antibacterial monomer 12-methacryloyloxydodecylpyridinium
bromide (MDPB) was effective in immobilizing bactericide in the resin matrix, and
an antibacterial composite without release of the agent could be achieved. In this
study, an attempt was made to increase the density of bactericide immobilized in composite,
and the inhibitory effects of this modified antibacterial composite on plaque accumulation
were determined, focusing on the reliability of the effects and the mechanisms to
affect the plaque formation.
An experimental composite containing immobilized bactericide at 2.83% was prepared
by the incorporation of MDPB into a prepolymerized resin filler of control composite,
and elution of antibacterial components and inhibition of in vitro plaque accumulation
by Streptococcus mutans were determined. The inhibitory effects of the experimental
composite on the attachment, glucan synthesis and growth of S. mutans on the surface
were also examined in addition to the comparison of surface roughness and hydrophobicity
with controls. The results were analyzed using the Student's t-test.
The experimental composite had reproducible inhibitory effects against plaque accumulation
compared with control (p<0.05), although it showed no elution of unpolymerized MDPB.
The plaque-inhibitory effect of the experimental composite was found to depend upon
the ability to inhibit the attachment, glucan synthesis, and growth of bacteria on
its surface as no significant differences in the surface characteristics were obtained
between control and experimental composites (p>0.05).
It was indicated that the experimental composite containing bactericide-immobilized
filler has the possibility to be used clinically with an effective anti-plaque property.