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      Vitamin D, Desferrioxamine and Aluminum-Induced Bone Disease in Uremic Rats

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          The effect of 100 ng 1α-OH vitamin D/week alone and in combination with desferrioxamine (DFO), 150 mg/week, was evaluated in aluminum loaded uremic rats. Vitamin D (Vit D) caused an increase of A1 in muscle and a decrease in serum A1. Bone histology showed mineralization defect and an increase in bone mass, due to an increase in unmineralized bone, induced both by A1 and Vit D administration. Treatment with DFO enhanced urinary Al excretion and lowered tissue A1, without inducing major changes of static bone histology. It is concluded that in A1-loaded uremic rats Vit D can redistribute body A1 and that both Al and Vit D can cause a mineralization defect. A 6-week treatment with DFO lowers tissue A1 without changing significantly static bone parameters.

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          Author and article information

          S. Karger AG
          10 December 2008
          : 53
          : 1
          : 54-60
          aDepartment of Medicine, Akademisch Ziekenhuis, bLaboratory for Pharmaceutical and Biochemical Analysis, Pharmaceutical Institute, and cDepartment of Pathology, Brugmann Ziekenhuis, Vrije Universiteit, Brussels, Belgium
          185702 Nephron 1989;53:54–60
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 7
          Original Paper

          Cardiovascular Medicine, Nephrology

          Desferrioxamine, Vitamin D, Aluminum, Renal osteodystrophy


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