Vitamin D, Desferrioxamine and Aluminum-Induced Bone Disease in Uremic Rats

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Abstract

The effect of 100 ng 1α-OH vitamin D/week alone and in combination with desferrioxamine (DFO), 150 mg/week, was evaluated in aluminum loaded uremic rats. Vitamin D (Vit D) caused an increase of A1 in muscle and a decrease in serum A1. Bone histology showed mineralization defect and an increase in bone mass, due to an increase in unmineralized bone, induced both by A1 and Vit D administration. Treatment with DFO enhanced urinary Al excretion and lowered tissue A1, without inducing major changes of static bone histology. It is concluded that in A1-loaded uremic rats Vit D can redistribute body A1 and that both Al and Vit D can cause a mineralization defect. A 6-week treatment with DFO lowers tissue A1 without changing significantly static bone parameters.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 10 December 2008

Volume: 53

Issue: 1

Pages: 54-60

Affiliations

^aDepartment of Medicine, Akademisch Ziekenhuis, ^bLaboratory for Pharmaceutical and Biochemical Analysis, Pharmaceutical Institute, and ^cDepartment of Pathology, Brugmann Ziekenhuis, Vrije Universiteit, Brussels, Belgium

Article

Publisher ID: 185702 Other ID: Nephron 1989;53:54–60

DOI: 10.1159/000185702

PubMed ID: 2779702

SO-VID: a4a95115-497c-4aab-8509-79a609a68387

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 20 December 1988

Page count

Pages: 7

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