Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders

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Abstract

Anxiety and depression disorders are highly prevalent neurological disorders (NDs) that impact up to one in three individuals during their lifetime. Addressing these disorders requires reducing their frequency and impact, understanding molecular causes, implementing prevention strategies, and improving treatments. Cyclic nucleotide monophosphates (cNMPs) like cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), cyclic uridine monophosphate (cUMP), and cyclic cytidine monophosphate (cCMP) regulate the transcription of genes involved in neurotransmitters and neurological functions. Evidence suggests that cNMP pathways, including cAMP/cGMP, cAMP response element binding protein (CREB), and Protein kinase A (PKA), play a role in the physiopathology of anxiety and depression disorders. Plant and mushroom-based compounds have been used in traditional and modern medicine due to their beneficial properties. Bioactive compound metabolism can activate key pathways and yield pharmacological outcomes. This review focuses on the molecular mechanisms of bioactive compounds from plants and mushrooms in modulating cNMP pathways. Understanding these processes will support current treatments and aid in the development of novel approaches to reduce the prevalence of anxiety and depression disorders, contributing to improved outcomes and the prevention of associated complications.

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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Roland R. Griffiths, Matthew W. Johnson, Michael A Carducci … (2016)

Cancer patients often develop chronic, clinically significant symptoms of depression and anxiety. Previous studies suggest that psilocybin may decrease depression and anxiety in cancer patients. The effects of psilocybin were studied in 51 cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety. This randomized, double-blind, cross-over trial investigated the effects of a very low (placebo-like) dose (1 or 3 mg/70 kg) vs. a high dose (22 or 30 mg/70 kg) of psilocybin administered in counterbalanced sequence with 5 weeks between sessions and a 6-month follow-up. Instructions to participants and staff minimized expectancy effects. Participants, staff, and community observers rated participant moods, attitudes, and behaviors throughout the study. High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety. At 6-month follow-up, these changes were sustained, with about 80% of participants continuing to show clinically significant decreases in depressed mood and anxiety. Participants attributed improvements in attitudes about life/self, mood, relationships, and spirituality to the high-dose experience, with >80% endorsing moderately or greater increased well-being/life satisfaction. Community observer ratings showed corresponding changes. Mystical-type psilocybin experience on session day mediated the effect of psilocybin dose on therapeutic outcomes. Trial Registration ClinicalTrials.gov identifier: NCT00465595

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The synapsins: key actors of synapse function and plasticity.

F Cesca, P. Baldelli, F Valtorta … (2010)

The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Their best-characterised function is to modulate neurotransmitter release at the pre-synaptic terminal, by reversibly tethering synaptic vesicles (SVs) to the actin cytoskeleton. However, many recent data have suggested novel functions for synapsins in other aspects of the pre-synaptic physiology, such as SV docking, fusion and recycling. Synapsin activity is tightly regulated by several protein kinases and phosphatases, which modulate the association of synapsins to SVs as well as their interaction with actin filaments and other synaptic proteins. In this context, synapsins act as a link between extracellular stimuli and the intracellular signalling events activated upon neuronal stimulation. Genetic manipulation of synapsins in various in vivo models has revealed that, although not essential for the basic development and functioning of neuronal networks, these proteins are extremely important in the fine-tuning of neuronal plasticity, as shown by the epileptic phenotype and behavioural abnormalities characterising mouse lines lacking one or more synapsin isoforms. In this review, we summarise the current knowledge about how the various members of the synapsin family are involved in the modulation of the pre-synaptic physiology. We give a comprehensive description of the molecular basis of synapsin function, as well as an overview of the more recent evidence linking mutations in the synapsin proteins to the onset of severe central nervous system diseases such as epilepsy and schizophrenia. (c) 2010 Elsevier Ltd. All rights reserved.

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Bound phenolics in foods, a review.

Phyllis Acosta, Pedro J A Gutiérrez, S O Serna-Saldívar (2013)

Among phytochemicals, phenolic compounds have been extensively researched due to their diverse health benefits. Phenolic compounds occur mostly as soluble conjugates and insoluble forms, covalently bound to sugar moieties or cell wall structural components. Absorption mechanisms for bound phenolic compounds in the gastrointestinal tract greatly depend on the liberation of sugar moieties. Food processes such as fermentation, malting, thermoplastic extrusion or enzymatic, alkaline and acid hydrolyses occasionally assisted with microwave or ultrasound have potential to release phenolics associated to cell walls. Different kinds of wet chemistry methodologies to release and detect bound phenolic have been developed. These include harsh heat treatments, chemical modifications or biocatalysis. New protocols for processing and determining phenolics in food matrices must be devised in order to release bound phenolics and for quality control in the growing functional food industry. Copyright © 2013 Elsevier Ltd. All rights reserved.

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Author and article information

Contributors

Citlaly Gutiérrez-Rodelo: citlalygutierrezrodelo@quimica.unam.mx

Andrés Navarrete-Castro: anavarrt@unam.mx

Journal

Journal ID (nlm-ta): Mol Biol Rep

Journal ID (iso-abbrev): Mol Biol Rep

Title: Molecular Biology Reports

Publisher: Springer Netherlands (Dordrecht )

ISSN (Print): 0301-4851

ISSN (Electronic): 1573-4978

Publication date (Electronic): 24 July 2023

Publication date PMC-release: 24 July 2023

Publication date (Print): 2023

Volume: 50

Issue: 9

Pages: 7797-7814

Affiliations

[1 ]GRID grid.9486.3, ISNI 0000 0001 2159 0001, Department of Pharmacy, Faculty of Chemistry, , National Autonomous University of Mexico (UNAM), ; Mexico City, ZIP 04510 Mexico

[2 ]Research Center in Applied Biotechnology of the National Polytechnic Institute, Tlaxcala, ZIP 90700 México

[3 ]GRID grid.418275.d, ISNI 0000 0001 2165 8782, Department of Physiology, Biophysics, and Neurosciences of the Center for Research, , Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), ; Mexico City, ZIP 07360 Mexico

[4 ]GRID grid.512574.0, Department of Biochemistry, , Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN) Mexico City, ; Mexico City, ZIP 07360 Mexico

Article

Publisher ID: 8650

DOI: 10.1007/s11033-023-08650-8

PMC ID: 10460744

PubMed ID: 37486442

SO-VID: a4f2f547-8feb-474c-a3ae-d9b56595326e

Copyright © © The Author(s) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 14 February 2023

Date accepted : 28 June 2023

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100006087, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México;

Award ID: IN203122

Award ID: IA208721

Funded by: Research Institute by the National Council of Science and Technology (CONACYT)

Award ID: A1-S-9698.

Custom metadata

ScienceOpen disciplines: Molecular biology

Keywords: plant bioactive,mushrooms bioactive,second messengers,signal pathways,anxiety,depression,cyclic nucleotide

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ScienceOpen disciplines: Molecular biology

Keywords: plant bioactive, mushrooms bioactive, second messengers, signal pathways, anxiety, depression, cyclic nucleotide

Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders

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Higher order chromatin architecture

Most cited references 56

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

The synapsins: key actors of synapse function and plasticity.

Bound phenolics in foods, a review.

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