Expression of miR-126 and its potential function in coronary artery disease

Abstract

<div class="section"> <a class="named-anchor" id="d5767853e138"> <!-- named anchor --> </a> <h5 class="section-title" id="d5767853e139">Objective</h5> <p id="d5767853e141">This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis. </p> </div><div class="section"> <a class="named-anchor" id="d5767853e143"> <!-- named anchor --> </a> <h5 class="section-title" id="d5767853e144">Methodology</h5> <p id="d5767853e146">A total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR. ELISA was used to measure plasma level of placenta growth factor (PLGF). </p> </div><div class="section"> <a class="named-anchor" id="d5767853e148"> <!-- named anchor --> </a> <h5 class="section-title" id="d5767853e149">Results</h5> <p id="d5767853e151">The results showed that the miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects (P&lt;0.01). Plasma PLGF level was significantly upregulated in patients with unstable angina pectoris and acute myocardial infarction (AMI) compared with controls (both P&lt;0.01) the miR-126 expression in AMI was significantly associated with PLGF. </p> </div><div class="section"> <a class="named-anchor" id="d5767853e153"> <!-- named anchor --> </a> <h5 class="section-title" id="d5767853e154">Conclusion</h5> <p id="d5767853e156">miR-126 may serve as a novel biomarker for CAD.</p> </div>