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Abstract
Triprolidine-containing matrix was fabricated with ethylene-vinyl acetate (EVA) copolymer
to control the release of the drug. The permeation rate of triprolidine in the stripped
skin was greatly larger than that in the whole skin. Thus it showed that the stratum
corneum acts as a barrier of skin permeation. The effect of penetration enhancer and
stripping of skin on the permeation of triprolidine through the excised mouse skin
was studied. Penetrating enhancers showed increased flux probably due to the enhancing
effect on the skin barrier, the stratum corneum. Among enhancers used such as glycols,
fatty acids and non-ionic surfactants, polyoxyethylene-2-oleyl ether showed the best
enhancement. The permeability of triprolidine was markedly increased with stripping
of the mouse skin to remove the stratum corneum that acts as a barrier of skin permeation.
For the controlling transdermal delivery of triprolidine, the application of EVA membrane
containing permeation enhancer could be useful in the development of transdermal drug
delivery system.