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Does Equi–Minimum Alveolar Concentration Value Ensure Equivalent Analgesic or Hypnotic Potency? : A Comparison between Desflurane and Sevoflurane
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Abstract
<p class="first" id="d13077382e81">Minimum alveolar concentration (MAC) has traditionally
been used to compare the potency
of volatile anesthetics. However, as it reflects the spinal mechanism of immobility
rather than the cerebral mechanism of analgesia and hypnosis, it is doubtful that
equi-MAC connotes equivalent analgesic or hypnotic potency. The level of analgesia
and hypnosis can be assessed using surgical pleth index and bispectral index (BIS)
values, respectively. This study was designed to compare the surgical pleth index
and BIS values produced by equi-MAC of desflurane and sevoflurane in patients undergoing
single-agent volatile anesthesia.
</p>