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Holoprosencephaly in infants of diabetic mothers
Mason Barr ,
James W. Hanson ,
Kathleen Currey ,
Stuart Sharp ,
Helga Toriello ,
Roy D. Schmickel ,
Golder N. Wilson
April 1983
April 1983
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Abstract
We report seven infants of diabetic mothers, affected with holoprosencephaly malformation
sequence. An additional 15 cases assembled from personal communications and the literature
indicate that holoprosencephaly, like neural tube, cardiac, and caudal defects, is
specifically increased in children of diabetic mothers. Incidence figures from newborn
surveys demonstrate a risk for holoprosencephaly in infants of diabetic mothers comparable
to the 1% risk for caudal regression malformation sequence. The embryologic timing
of cranial, cardiac, and caudal defects emphasizes the need for pregnancy planning
and diabetes control.