Manoj Kumar 1 , * , Vivek Saurabh 2 , Maharishi Tomar 3 , Muzaffar Hasan 4 , Sushil Changan 5 , Minnu Sasi 6 , Chirag Maheshwari 7 , Uma Prajapati 2 , Surinder Singh 8 , Rakesh Kumar Prajapat 9 , Sangram Dhumal 10 , Sneh Punia 11 , Ryszard Amarowicz 12 , Mohamed Mekhemar 13 , *
16 February 2021
Mangifera indica L. belongs to the family of Anacardiaceae and is an important fruit from South and Southeast Asia. India, China, Thailand, Indonesia, Pakistan, Mexico, Brazil, Bangladesh, Nigeria, and the Philippines are among the top mango producer countries. Leaves of the mango plant have been studied for their health benefits, which are attributed to a plethora of phytochemicals such as mangiferin, followed by phenolic acids, benzophenones, and other antioxidants such as flavonoids, ascorbic acid, carotenoids, and tocopherols. The extracts from mango leaves (MLs) have been studied for their biological activities, including anti-cancer, anti-diabetic, anti-oxidant, anti-microbial, anti-obesity, lipid-lowering, hepato-protection, and anti-diarrheal. In the present review, we have elaborated on the nutritional and phytochemical profile of the MLs. Further, various bioactivities of the ML extracts are also critically discussed. Considering the phytochemical profile and beneficial effects of the MLs, they can be used as a potential ingredient for the development of functional foods and pharmaceutical drugs. However, more detailed clinical trials still needed to be conducted for establishing the actual efficacy of the ML extracts.