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      Surface-enhanced Raman scattering (SERS)–based immunosystem for ultrasensitive detection of the 90K biomarker

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          Abstract

          The research and the individuation of tumour markers in biological fluids are currently one of the main tools to support diagnosis, prognosis, and monitoring of the therapeutic response in oncology. Although the identification of tumour markers in asymptomatic patients is crucial for early diagnosis, its application is still limited by the relatively low sensitivity and the complexity of existing methods (i.e. ELISA, mass spectrometry). We developed an easy, fast, and ultrasensitive surface-enhanced Raman scattering (SERS)–based system, for the detection and quantitation of the LGALS3BP (90K) biomarker that was used as a model, based on the development of antibody-functionalized nanostructured gold surfaces. The detection system was effective for the ultrasensitive detection and characterization of samples of different biochemical compositions. In conclusion, this work could provide the foundation for the development of a medical diagnostic device with the highest predictive power when compared with the methods currently used in cancer diagnostics.

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          The online version of this article (10.1007/s00216-020-02903-2) contains supplementary material, which is available to authorized users.

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          Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering

          Nie, Emory (1997)
          Optical detection and spectroscopy of single molecules and single nanoparticles have been achieved at room temperature with the use of surface-enhanced Raman scattering. Individual silver colloidal nanoparticles were screened from a large heterogeneous population for special size-dependent properties and were then used to amplify the spectroscopic signatures of adsorbed molecules. For single rhodamine 6G molecules adsorbed on the selected nanoparticles, the intrinsic Raman enhancement factors were on the order of 10(14) to 10(15), much larger than the ensemble-averaged values derived from conventional measurements. This enormous enhancement leads to vibrational Raman signals that are more intense and more stable than single-molecule fluorescence.
          Article 0 comments Cited 388 times – based on 0 reviews     Review now
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            Cancer treatment and survivorship statistics, 2012.

            Rebecca Siegel, Carol DeSantis, Katherine Virgo … (2012)
            Although there has been considerable progress in reducing cancer incidence in the United States, the number of cancer survivors continues to increase due to the aging and growth of the population and improvements in survival rates. As a result, it is increasingly important to understand the unique medical and psychosocial needs of survivors and be aware of resources that can assist patients, caregivers, and health care providers in navigating the various phases of cancer survivorship. To highlight the challenges and opportunities to serve these survivors, the American Cancer Society and the National Cancer Institute estimated the prevalence of cancer survivors on January 1, 2012 and January 1, 2022, by cancer site. Data from Surveillance, Epidemiology, and End Results (SEER) registries were used to describe median age and stage at diagnosis and survival; data from the National Cancer Data Base and the SEER-Medicare Database were used to describe patterns of cancer treatment. An estimated 13.7 million Americans with a history of cancer were alive on January 1, 2012, and by January 1, 2022, that number will increase to nearly 18 million. The 3 most prevalent cancers among males are prostate (43%), colorectal (9%), and melanoma of the skin (7%), and those among females are breast (41%), uterine corpus (8%), and colorectal (8%). This article summarizes common cancer treatments, survival rates, and posttreatment concerns and introduces the new National Cancer Survivorship Resource Center, which has engaged more than 100 volunteer survivorship experts nationwide to develop tools for cancer survivors, caregivers, health care professionals, advocates, and policy makers. Published 2012 American Cancer Society, Inc.
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              The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry

              Tao Gong, Weixian Xi, Maciej Podgórski … (2014)
              Article 0 comments Cited 196 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Giovanni Antonini: giovanni.antonini@uniroma3.it
                Journal
                Journal ID (nlm-ta): Anal Bioanal Chem
                Journal ID (iso-abbrev): Anal Bioanal Chem
                Title: Analytical and Bioanalytical Chemistry
                Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )
                ISSN (Print): 1618-2642
                ISSN (Electronic): 1618-2650
                Publication date (Electronic): 2 September 2020
                Publication date PMC-release: 2 September 2020
                Publication date (Print): 2020
                Volume: 412
                Issue: 27
                Pages: 7659-7667
                Affiliations
                [1 ]GRID grid.419691.2, ISNI 0000 0004 1758 3396, Interuniversity Consortium INBB - Biostructures and Biosystems National Institute, ; 00136 Rome, Italy
                [2 ]GRID grid.5196.b, ISNI 0000 0000 9864 2490, ENEA, ; Via Enrico Fermi 45, 00044 Frascati, Italy
                [3 ]Mediapharma srl, 66100 Chieti, Italy
                [4 ]GRID grid.8509.4, ISNI 0000000121622106, Department of Sciences, , University Roma Tre, ; Viale G. Marconi 446, 00146 Rome, Italy
                Article
                Publisher ID: 2903
                DOI: 10.1007/s00216-020-02903-2
                PMC ID: 7533257
                PubMed ID: 32875368
                SO-VID: a7b9b24d-1fd0-4746-a845-da196dbe3d34
                Copyright © © The Author(s) 2020
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 5 June 2020
                Date revision received : 7 August 2020
                Date accepted : 19 August 2020
                Funding
                Funded by: LazioInnova, ADVISER (Automatic DeVIce for Smart dEtection of tumouRs) project, POR FESR Lazio 2014-2020, CUP F85F18000070007
                Award ID: CUP F85F18000070007
                Funded by: National Funding for Centers of Excellence (Science Department, Roma Tre University - MIUR, Articolo 1, Commi 314–337 Legge 232/2016).
                Categories
                Subject: Research Paper
                Custom metadata
                issue-copyright-statement © Springer-Verlag GmbH Germany, part of Springer Nature 2020

                ScienceOpen disciplines: Analytical chemistry
                Keywords: surface-enhanced raman spectroscopy (sers),sers substrates,biomarkers,lgal3bp,bioanalytical methods
                Data availability:
                ScienceOpen disciplines: Analytical chemistry
                Keywords: surface-enhanced raman spectroscopy (sers), sers substrates, biomarkers, lgal3bp, bioanalytical methods

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