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      Pharmacological Action of 5’-Methylthioadenosine on Isolated Rabbit Aorta Strips

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          The effects of 5’-methylthioadenosine (MTA) and adenosine analogues on isolated rabbit thoracic aorta strips were studied in vitro. High concentrations (500–1,000 µM) of adenosine analogues produced dose-dependent relaxation in isolated rabbit thoracic aorta strips. The relative potencies of relaxant effect were MTA& > N6-phenylisopropyladenosine& > 2-chloroadenosine on a molar basis. MTA (50–1,000 µM) suppressed the contraction induced by norepinephrine in isolated rabbit thoracic aorta strips in a concentration-dependent manner. Nucleoside uptake inhibitor dipyridamole did not impair the MTA actions. Pretreatment of the aorta strips with theophylline, an adenosine receptor antagonist, blocked the actions of MTA. MTA showed a relaxant effect in KCl-contracted aorta suggesting that MTA did not affect the metabolism or reuptake of norepinephrine. The present experiments suggest that MTA has a pharmacological action on the arterial smooth muscle cells mediated through adenosine receptors.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 22
          : 5
          : 229-233
          Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
          158606 Blood Vessels 1985;22:229–233
          © 1985 S. Karger AG, Basel

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          Pages: 5
          Research Paper


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