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      English Version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021.

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          This is the English version of the Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021. Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. In Japan, from the perspective of evidence-based medicine, the current strategies for the treatment of AD consist of three primary measures: (i) use of topical corticosteroids, tacrolimus ointment, and delgocitinib ointment as the main treatment of the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling, and advice about daily life. In the present revised guidelines, descriptions of three new drugs, namely, dupilumab, delgocitinib, and baricitinib, have been added. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice.

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          Author and article information

          J Dermatol
          The Journal of dermatology
          Oct 2022
          : 49
          : 10
          [1 ] Department of Dermatology, Nippon Medical School, Tokyo, Japan.
          [2 ] Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
          [3 ] Medical Informatics and Management, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
          [4 ] Kitakanto Allergy Research Institute, Kibounoie Hospital, Midori, Japan.
          [5 ] Department of Pediatrics, The Jikei University Daisan Hospital, Tokyo, Japan.
          [6 ] Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
          [7 ] Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
          [8 ] Department of Dermatology, Saitama Medical University, Saitama, Japan.
          [9 ] Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
          [10 ] Allergy Center, National Hospital Organization Mie National Hospital, Tsu, Japan.
          [11 ] Department of Pediatrics, Faculty of Medicine, Kyorin University, Tokyo, Japan.
          [12 ] Department of Dermatology, Hiroshima Citizens Hospital, Hiroshima, Japan.
          [13 ] Division of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
          [14 ] Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
          [15 ] Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

          atopic dermatitis,clinical questions,evidence-based medicine,treatment,clinical practice guidelines


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