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Epithelium-derived Cystatin-SN enhances eosinophil activation and infiltration via interleukin-5 in chronic rhinosinusitis with nasal polyps
Bing Yan ,
Hongfei Lou ,
Yang Wang ,
Ying Li ,
Yifan Meng ,
Sihan Qi ,
Ming Wang ,
Lei Xiao ,
Chengshuo Wang ,
Luo Zhang
April 2019
April 2019
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Abstract
The interaction between epithelial cells and immune cells plays an important role
in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP); however,
the mechanism or mechanisms underlying TH-biased inflammation in this process are
largely unknown. Profiling protein expression in patients with CRSwNP by using shotgun
proteomics suggested that cystatin SN (CST1), a type 2 cysteine protease inhibitor,
might play a role because this was expressed with the greatest difference in patients
with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and those with
noneosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP).