Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry

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Abstract

This review is an attempt to summarize current research on ozone, titanium dioxide (TiO ₂), silver (Ag), copper oxide CuO and platinum (Pt) nanoparticles (NPs). These agents can be used in various fields of dentistry such as conservative dentistry, endodontic, prosthetic or dental surgery. Nanotechnology and ozone can facilitate the dentist’s work by providing antimicrobial properties to dental materials or ensuring a decontaminated work area. However, the high potential of these agents for use in medicine should be confirmed in further research due to possible side effects, especially in long duration of observation so that the best way to apply them can be obtained.

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Oral diseases: a global public health challenge

Marco A. Peres, Lorna M D Macpherson, Robert J. Weyant … (2019)

Oral diseases are among the most prevalent diseases globally and have serious health and economic burdens, greatly reducing quality of life for those affected. The most prevalent and consequential oral diseases globally are dental caries (tooth decay), periodontal disease, tooth loss, and cancers of the lips and oral cavity. In this first of two papers in a Series on oral health, we describe the scope of the global oral disease epidemic, its origins in terms of social and commercial determinants, and its costs in terms of population wellbeing and societal impact. Although oral diseases are largely preventable, they persist with high prevalence, reflecting widespread social and economic inequalities and inadequate funding for prevention and treatment, particularly in low-income and middle-income countries (LMICs). As with most non-communicable diseases (NCDs), oral conditions are chronic and strongly socially patterned. Children living in poverty, socially marginalised groups, and older people are the most affected by oral diseases, and have poor access to dental care. In many LMICs, oral diseases remain largely untreated because the treatment costs exceed available resources. The personal consequences of chronic untreated oral diseases are often severe and can include unremitting pain, sepsis, reduced quality of life, lost school days, disruption to family life, and decreased work productivity. The costs of treating oral diseases impose large economic burdens to families and health-care systems. Oral diseases are undoubtedly a global public health problem, with particular concern over their rising prevalence in many LMICs linked to wider social, economic, and commercial changes. By describing the extent and consequences of oral diseases, their social and commercial determinants, and their ongoing neglect in global health policy, we aim to highlight the urgent need to address oral diseases among other NCDs as a global health priority.

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Metal nanoparticles: understanding the mechanisms behind antibacterial activity

Yael Slavin, Jason Asnis, Urs Häfeli … (2017)

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

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Antimicrobial activity of metals: mechanisms, molecular targets and applications.

Joseph A. Lemire, Joe Harrison, Raymond J. Turner (2013)

Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.

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Journal

Journal ID (nlm-ta): Nanomaterials (Basel)

Journal ID (iso-abbrev): Nanomaterials (Basel)

Journal ID (publisher-id): nanomaterials

Title: Nanomaterials

Publisher: MDPI

ISSN (Electronic): 2079-4991

Publication date (Electronic): 20 January 2021

Publication date Collection: February 2021

Volume: 11

Issue: 2

Electronic Location Identifier: 259

Affiliations

[1 ]Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wrocław, Poland; adam.lubojanski@ 123456student.umed.wroc.pl (A.L.); wojciech.zakrzewski@ 123456student.umed.wroc.pl (W.Z.); maria.szymonowicz@ 123456umed.wroc.pl (M.S.); zbigniew.rybak@ 123456umed.wroc.pl (Z.R.)

[2 ]Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wrocław, Poland; maciej.dobrzynski@ 123456umed.wroc.pl

[3 ]Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland; n.nowak@ 123456intibs.pl (N.N.); j.rewak@ 123456intibs.pl (J.R.-S.)

[4 ]Department of Pediatric Dentistry, Academic Dental Polyclinics, Krakowska 26, 50-435 Wroclaw, Poland; klaudia.sztyler1@ 123456gmail.com

[5 ]Student Scientific Circle at the Department of Dental Materials, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Akademicki Sq. 17, 41-902 Bytom, Poland; wojt.dobrzynski@ 123456wp.pl

[6 ]Department of Analytical Chemistry, Wroclaw Medical University, Borowska 211 A, 50-566 Wroclaw, Poland; katarzyna.wiglusz@ 123456umed.wroc.pl

Author notes

[* ]Correspondence: r.wiglusz@ 123456intibs.pl ; Tel.: +48-71-3954-159; Fax: +48-71-344-10-29

Author information

Maciej Dobrzynski https://orcid.org/0000-0003-2368-1534

Justyna Rewak-Soroczynska https://orcid.org/0000-0002-8139-144X

Zbigniew Rybak https://orcid.org/0000-0002-8988-1515

Rafal J. Wiglusz https://orcid.org/0000-0001-8458-1532

Article

Publisher ID: nanomaterials-11-00259

DOI: 10.3390/nano11020259

PMC ID: 7909445

PubMed ID: 33498453

SO-VID: a81459c7-507a-48a7-80ff-4a3c53c11664

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry

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Abstract

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Photoluminescent Nanomaterials

Most cited references 206

Oral diseases: a global public health challenge

Metal nanoparticles: understanding the mechanisms behind antibacterial activity

Antimicrobial activity of metals: mechanisms, molecular targets and applications.

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