Jonathan Carruthers: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Grant Lythe:
ORCID: http://orcid.org/0000-0001-7966-5571
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Martín López-García:
ORCID: http://orcid.org/0000-0003-3833-8595
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Joseph Gillard:
ORCID: http://orcid.org/0000-0001-7486-8927
Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Thomas R. Laws:
ORCID: http://orcid.org/0000-0002-0142-9162
Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Roman Lukaszewski: Role: Investigation
Carmen Molina-París:
ORCID: http://orcid.org/0000-0001-9828-6737
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
James O’Dwyer: Role: Editor
Journal ID (nlm-ta): PLoS Comput Biol
Journal ID (iso-abbrev): PLoS Comput. Biol
Journal ID (publisher-id): plos
Journal ID (pmc): ploscomp
Title:
PLoS Computational Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-734X
ISSN
(Electronic):
1553-7358
Publication date Collection:
June
2020
Publication date
(Electronic):
1
June
2020
Volume: 16
Issue: 6
Electronic Location Identifier: e1007752
Affiliations
[1
]
Department of Applied Mathematics, University of Leeds, Leeds, United Kingdom
[2
]
CBR Division, Defence Science and Technology Laboratory, Salisbury, United Kingdom
University of Illinois at Urbana-Champaign, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PCOMPBIOL-D-19-01195
DOI: 10.1371/journal.pcbi.1007752
PMC ID: 7304631
PubMed ID: 32479491
SO-VID: a8444970-dd7d-4359-8a64-4090e465cfd7
Copyright © © 2020 Carruthers et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100009187, Medical Research Foundation;
Award ID: MR/N014855/1
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3833-8595
Martin Lopez-Garcia
The experimental work shown here was funded by the UK Ministry of Defence. Mathematical
research was supported by the Medical Research Council through the Skills Development
Fellowship number MR/N014855/1 MLG. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Respiratory System
Subject:
Lungs
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Respiratory System
Subject:
Lungs
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Francisella Tularensis
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Francisella Tularensis
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Francisella
Subject:
Francisella Tularensis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cytosol
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Dose Prediction Methods
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Respiratory Infections
Subject:
Research and Analysis Methods
Subject:
Simulation and Modeling
Subject:
Agent-Based Modeling
Subject:
Computer and Information Sciences
Subject:
Systems Science
Subject:
Agent-Based Modeling
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Systems Science
Subject:
Agent-Based Modeling
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Intracellular Pathogens