Inviting an author to review:
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
6
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Técnicas de trasplante hepático usadas en el manejo del carcinoma renal de células claras con trombos en la cava inferior que ascienden hasta el diafragma: serie de casos Translated title: Liver transplant techniques used in the management of clear renal cell carcinoma with thrombi in the inferior vena cava that ascend to the diaphragm: case series

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resumen Introducción. El carcinoma de células renales corresponde al 3 % de todos los tumores sólidos y, de ellos, cerca del 10 % tiene compromiso de la vena cava inferior. La nefrectomía con trombectomía es la mejor alternativa con intención curativa. La mortalidad perioperatoria se encuentra entre el 2 y el 11 %. El objetivo del presente estudio fue presentar una serie de casos de carcinomas renales con trombos de tipo III según la clasificación de Neves-Zincke, en los cuales se usaron con éxito técnicas del trasplante hepático para su extracción. Materiales y métodos. Se presenta una serie de cinco casos, de pacientes sometidos a nefrectomía radical y que presentaban trombo de la vena cava inferior, atendidos en el periodo comprendido entre enero de 2012 y septiembre de 2018. Resultados. De 26 pacientes encontrados con cáncer de células renales, se seleccionaron cinco con trombos de tipo Neves III, cuatro de ellos de tipo IIIa y uno de tipo IIIc. El promedio de edad fue de 63,2 años, cuatro mujeres y un hombre. El promedio de tiempo operatorio fue de 274 minutos y el de pinzamiento de la vena cava inferior fue de 13,6 minutos. El tiempo promedio de estancia en la unidad de cuidados intensivos fue de 2,8 días y el de estancia hospitalaria fue de 9,6 días. Un paciente no presentó ninguna complicación, y los cuatro restantes presentaron complicaciones quirúrgicas menores, I y II de la clasificación de Clavien-Dindo. Conclusión. El uso de maniobras técnicas del trasplante hepático para extraer trombos de la vena cava inferior que no comprometen la aurícula derecha en pacientes con tumores renales, es una alternativa segura con baja morbimortalidad perioperatoria y que puede llegar a garantizar el control de la enfermedad a largo plazo.

          Translated abstract

          Abstract Introduction. Renal cell carcinoma corresponds to 3% of all solid tumors and about 10% have IVC thrombus. Nephrectomy with thrombectomy is the best choice for a curative treatment. Perioperative mortality may vary between 2 and 11%. The aim of this study is to describe a series of patients with renal tumors and IVC thrombus Neves III in treated succesfully with liver transplant techniques. Materials and methods . We conducted a descriptive case series of five patients who underwent nephrectomy and thrombectomy between January 2012 and September 2018. Results . Of 26 nephectomized patients who had any IVC thrombus, five cases had renal tumors and thrombus Neves III. The mean age was 63.2 years and 80% were women. Eighty percent were Neves IIIa. Mean operative time and IVC clamping were 274 and 13.6 minutes respectively. ICU and hospital stay were 2.8 and 9.6 days. Twenty percent of patients had no complications, the rest had minor complications (Clavien-Dindo I and II). Conclusion. IVC thrombus extraction with liver transplantion technique for renal tumors without right atrium involvement is a safe alternative for patients with low morbility and mortality. It is also a feasible alternative to ensure disease control in a long term.

          Related collections

          Most cited references20

          • Record: found
          • Abstract: found
          • Article: not found

          Surgical treatment of renal cancer with vena cava extension.

          Fifty-four patients with renal cancer and vena cava tumour thrombus underwent radical nephrectomy and removal of the thrombus; the operative mortality rate was 9.3% (5 patients). The extent of the vena cava thrombus did not affect survival. Of 36 patients with no known pre-operative metastases and complete (29 patients) and incomplete (7 patients) removal of the vena cava tumour thrombus, the 5-year survival rate was 68 and 17%, respectively (P = 0.01). Thirteen patients (45%) who underwent complete removal of the vena cava tumour thrombus are alive and free of disease, with a mean follow-up of 51.2 months (range 4-144); three died without disease 110, 31 and 23 months after operation. The 2-year and 5-year survival rates of 18 patients with known pre-operative metastases was 37.5 and 12.5% respectively; 14 died between 1 and 27 months post-operatively (mean 11.6) of metastatic disease. Two of these 18 patients experienced long-term remission: one died of unrelated causes 151 months after operation; the other was lost to follow-up 219 months after operation, with no evidence of disease. Of 14 patients with positive regional nodes, the mean survival in those with metastases compared with those without metastases was 7.5 versus 15 months, respectively; only one patient survived at 14 months. Operative intervention in patients without metastatic disease (systemic or regional) and complete removal of the vena cava thrombus achieved a 5-year survival rate of 68%. Variables which significantly decreased survival and may be considered contraindications for operation were systemic metastasis, regional lymph node involvement and incomplete removal of the vena cava thrombus.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Orthotopic liver transplantation with preservation of the inferior vena cava.

            Piggyback orthotopic liver transplantation was performed in 24 patients during a period of 4 months. This represented 19% of the liver transplantation at our institution during that time. The piggyback method of liver insertion compared favorably with the standard operation in terms of patient survival, blood loss, incidence of vascular and biliary complications, and rate of retransplantation. The piggyback operation cannot be used in all cases, but when indicated and feasible its advantages are important enough to warrant its inclusion in the armamentarium of the liver transplant surgeon.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Natural history of untreated renal cell carcinoma with venous tumor thrombus.

              The natural history of untreated renal cell carcinoma (RCC) with venous tumor thrombus (VTT) is poorly characterized. We aimed to describe the natural history of this disease, and to identify prognostic factors associated with disease-specific survival. We identified patients in the Surveillance, Epidemiology, and End Results (SEER) database with untreated renal cell carcinoma and venous tumor thrombi. Disease-specific median and 1-year survival rates were determined, and disease-free survival curves were plotted using the Kaplan-Meier method. Multivariable Cox regression analyses were performed to identify factors associated with disease-specific and overall survival in this patient group. Of 2,265 patients with RCC and VTT, 390 (17%) underwent no treatment; 278 (71%) patients died during follow-up; of these, 243 deaths (87%) were due to RCC. Median and 1-year disease-specific survival for this group was 5 months and 29%, respectively. On multivariable analysis, the extent of tumor thrombus (HR 1.7 for T3c vs. T3b, 95% CI 1.0-2.7) and the presence of metastases (HR 3.1 for M+ vs. M0, 95% CI 1.7-5.5) were most strongly associated with disease-specific mortality. Prognosis is poor for the majority of untreated patients with RCC and VTT. Supradiaphragmatic thrombi and distant metastases are adverse prognostic factors in this patient group. This information is important when counseling patients as to the risk and benefits of surgical vs. nonoperative management of RCC and VTT. Copyright © 2013 Elsevier Inc. All rights reserved.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rcci
                Revista Colombiana de Cirugía
                rev. colomb. cir.
                Asociación Colombiana de Cirugía (Bogotá, Distrito Capital, Colombia )
                2011-7582
                2619-6107
                September 2019
                : 34
                : 3
                : 260-268
                Affiliations
                [2] Antioquía orgnameUniversidad de Antioquia orgdiv1Departamento de Urología Colombia
                [1] Medellín Antioquía orgnameUniversidad de Antioquia orgdiv1IPS Universitaria Colombia
                Article
                S2011-75822019000300260
                10.30944/20117582.442
                a8a82d6b-abc7-4f4d-8df8-80173e0680ea

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 19 October 2018
                : 08 March 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 21, Pages: 9
                Product

                SciELO Colombia

                Categories
                Artículos originales

                neoplasias renales,vena cava inferior,trombosis,procedimientos quirúrgicos,trasplante de hígado,kidney neoplasms,vena cava, inferior,thrombosis,surgical procedures,liver transplantation

                Comments

                Comment on this article