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Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST).
Ronald P Dematteo
1 ,
Jason S Gold ,
Lisa Saran ,
Mithat Gönen ,
Kui Hin Liau ,
Robert G Maki ,
Samuel Singer ,
Peter Besmer ,
Murray F Brennan ,
Cristina R Antonescu
Feb 01 2008
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Abstract
Gastrointestinal stromal tumor (GIST) is the most frequent sarcoma of the intestinal tract and often shows constitutive activation of either the KIT or PDGFRA receptor tyrosine kinases because of gain-of-function mutation. Although the efficacy of tyrosine kinase inhibitors in metastatic GIST depends on tumor mutation status, there have been conflicting reports on the prognostic importance of KIT mutation in primary GIST.