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      Paravertebral Osteolipoma

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      1 , , 2
      Asian Spine Journal
      Korean Society of Spine Surgery

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          Abstract

          Dear Editor, We read with great interest the case report entitled "Cervical paravertebral osteolipoma: case report and literature review" in the issue of Asian Spine J 2015;9(2):290-4 [1]. We would like to congratulate the authors for their analysis of this complex and challenging case. However, we have some concerns regarding the case report and wish to share them. Osteolipoma, a lipoma with osseous metaplasia, is a very rare histological variant accounting for less than 1% of all lipomas [2 3 4]. It is seen in many anatomic sites, including the scapula, vertebral spine, neck, skull, suprasellar region, and tuber cinereum [2 3 4]. The differential diagnosis of osteolipoma also includes liposarcoma which is not mentioned in the article. Results of magnetic resonance imaging evaluation of 126 consecutive fatty masses by Gaskin and Helms [5] showed that osteolipoma may mimic well-differentiated liposarcomas, from which they are often hard to differentiate on imaging alone. Differentiation and definitive diagnosis of the osteolipoma can be done with histopathologic examination and treatment is by surgical excision. In addition, the identification of histological subtypes in already known variants of lipoma, such as low-fat and fat free spindle cell lipomas, highlight the importance for careful microscopic evaluation of these tumors [1 2 3 4]. As a conclusion we are of the opinion that the diagnosis of osteolipoma is not straightforward, and complete surgical resection is the treatment of choice. Like conventional lipomas, the prognosis of osteolipoma is favorable, but lesions should be monitored carefully and postoperative close monitoring with long-term follow-up is recommended, as there is only a minority of relevant clinical information about this rare tumor. Again we appreciate the authors' work, which adds to our knowledge of this difficult clinical problem.

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          Osteolipoma of the palate: report of a case and review of the literature.

          Oral lipomas, though rare, predominantly affect the buccal mucosa, tongue, and lips. The occurrence of lipomas in the palate is extremely rare. Osteolipoma is a very rare histological variant of lipoma accounting for less than 1% of all cases. Although a few cases involving the soft palate have been reported, there is only one reported case of osteolipoma of the hard palate in the English-language literature and it was a congenital osteolipoma associated with a cleft palate in a 6-year-old male child. This paper aims to describe an additional case uniquely located in the hard palate of an adult female.
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            Pure Intramuscular Osteolipoma

            Ossified lipoma or osteolipoma are rarely reported. It is defined as a histologic variant of lipoma that has undergone osseous metaplasia. Osteolipoma presents with a dominant osseous component within a lipoma. We report a case of a histologically confirmed osteolipoma on the nuchal ligament independent of bone. The patient was a 51-year-old female who presented with a 5-year history of a painless, progressively enlarging mass on the posterior neck. Computed tomography and magnetic resonance imaging showed a circumscribed mass compatible with fat between the C2 and C6 spinous processes with a large calcified irregular component. The mass with dual components was totally removed under general anesthesia and no recurrence was observed after 6 months of follow-up. We also reviewed the clinicopathologic features of previously reported osteolipomas in the literature and suggest that although osteolipoma is a rare variant of lipoma, it should be considered in the differential diagnosis when a lipoma of the posterior neck mixed with a bony component is encountered.
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              Osteolipoma of the palate – An unusual presentation

              Sir, Although not common in the mouth, lipoma is the most common benign mesenchymal neoplasia of soft tissues in adults.[1] Around 20% of the cases involve the head and neck region and only 1–4% occur in the oral cavity.[1 2] Osteolipoma is very rare variant of lipoma accounts for less than 1% of all the cases.[3] Oral lipomas mostly occur in the buccal mucosa, floor of the mouth, tongue, and lips. Only two cases of osteolipoma of the palate have been reported in English literature: One was congenital osteolipoma associated with a cleft palate in a 6-year-old male child[4] and the second was reported in a 37-year-old female Nigerian patient.[5] We present a rare case of osteolipoma of the hard palate in a 55-year-old male patient. A 55-year-old male presented with a chief complaint of palatal swelling posterior to the incisive papilla from 4 years. Both the past medical history and systemic signs are not relevant with the case. Extraoral examination did not reveal any abnormality. On intraoral examination a yellowish pink firm-to-hard palatal swelling measuring about 1.5 × 1.5 cm was noted [Figure 1]. Figure 1 Yellowish pink firm-to-hard palatal swelling The swelling was nontender on palpation and overlying mucosa was normal in color without showing any signs of ulceration and erythema. On radiographic examination by oclusal radiographs, a patchy area of radiopacity was revealed. On the basis of clinical features, provisional diagnosis of ossifying fibroma was made. The lesion was surgically excised under local anesthesia by raising the mucoperiosteal flap and a soft yellowish white mass measuring 1.5 × 1 cm [Figure 2] was sent for the histopathological examination. Microscopical examination revealed normal bony trabeculae with the features of osteoblastic rimming, surrounded by mature adipocytes with compressed nuclei at the cell border [Figure 3]. Connective tissue septa were found intervening the adipocytes at places [Figure 4]. No dysplastic features were noted. On the basis of all the histopathological features, a final diagnosis of osteolipoma was established. Follow-up visits were uneventful. Figure 2 Gross tissue sent for histopathological examination Figure 3 Bony trabeculae surrounded by mature adipocytes Figure 4 Connective tissue septa intervening adipocytes Many benign histological variants of lipoma are known and described based on the type of tissue present and predominant in the lesion: Fibrolipoma, angiolipoma, myolipoma, myxolipoma, spindle cell lipoma, osteolipoma, and chondrolipoma.[1 2 3 4 5 6] Lipomas with osseous or cartilaginous metaplasia is a rare histological variant. Osteolipoma is a variant of lipoma that shows osseous metaplasia accounts for less than 1%[4] and is seen at many extra-oral sites including scapula, vertebral spine, neck, skull, suprasellar region, and tuber cinereum.[4 6] A differential diagnosis suggesting osteolipoma primarily depends on its location. Because of the various anatomic sites reported for this lesion, a very wide range of lesions can be included in the differential diagnosis, such as other benign tumors that may contain bone including teratoma[2] In addition, tumor calcinosis, ossifying fibroma, central hemangioma, and myositis ossificans should also be considered.[2 6] Soft-tissue sarcomas that can show calcification or ossification include liposarcoma, synovial sarcoma, osteosarcoma, and chondrosarcoma. Soft-tissue chondromas, which are also rare, are frequently mineralized. Also some series showed that osteolipoma mimicked well-differentiated liposarcoma.[4] The diagnosis of oteolipoma is easy, and surgical excision is the treatment of choice. The prognosis of osteolipoma is favorable like conventional lipomas, but lesions should be monitored carefully and postoperative follow-up is also required as not much information is available pertaining to this rare tumor.
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                Author and article information

                Journal
                Asian Spine J
                Asian Spine J
                ASJ
                Asian Spine Journal
                Korean Society of Spine Surgery
                1976-1902
                1976-7846
                December 2015
                08 December 2015
                : 9
                : 6
                : 997-998
                Affiliations
                [1 ]Department of Orthopaedics and Traumatology, Aksaz Military Hospital, Marmaris, Turkey.
                [2 ]Department of Orthopaedics and Traumatology, Balikesir University Hospital, Balikesir, Turkey.
                Author notes
                Corresponding author: Selahattin Ozyurek. Department of Orthopaedics and Traumatology, Aksaz Military Hospital, 48700 Marmaris, Mugla, Turkey. Tel: +90-252-4210161, Fax: +90-252-412-1877, fsozyurek@ 123456yahoo.com
                Article
                10.4184/asj.2015.9.6.997
                4686411
                a9eaf67f-b550-43af-9177-a2376e1eec53
                Copyright © 2015 by Korean Society of Spine Surgery

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 04 May 2015
                : 05 May 2015
                Categories
                Letter to the Editor

                Orthopedics
                Orthopedics

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