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The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection
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Abstract
Epigallocatechin gallate is the most abundant composition of the tea catechins and
is thought to be responsible for the majority of biological activity of green tea
extracts such as antioxidant, anti-inflammatory, and antiapoptotic effects. Meanwhile,
EGCG has been shown to be some of the neuroprotective effects against neural injuries
and neurodegenerative diseases. This paper summarizes current knowledge on neuroprotective
effects of EGCG and their molecular mechanisms responsible for the neuroprotection
in various models of neurodegenerative and neural injury.