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      The skin microbiome in the first year of life and its association with atopic dermatitis

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          Abstract

          Early-life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbiome and AD, skin barrier integrity and allergic diseases in the first year of life. We further explored the evolution of the skin microbiome with age and its possible determinants, including delivery mode.

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          DADA2: High resolution sample inference from Illumina amplicon data

          Benjamin J. Callahan, Paul McMurdie, Michael Rosen … (2016)
          We present DADA2, a software package that models and corrects Illumina-sequenced amplicon errors. DADA2 infers sample sequences exactly, without coarse-graining into OTUs, and resolves differences of as little as one nucleotide. In several mock communities DADA2 identified more real variants and output fewer spurious sequences than other methods. We applied DADA2 to vaginal samples from a cohort of pregnant women, revealing a diversity of previously undetected Lactobacillus crispatus variants.
          Article 0 comments Cited 8128 times – based on 0 reviews     Review now
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            Interaction between microbiota and immunity in health and disease

            Danping Zheng, Timur Liwinski, Eran Elinav (2020)
            The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host’s innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and disease, while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs. We highlight aspects of the current knowledge, challenges and limitations in achieving causal understanding of host immune-microbiome interactions, as well as their impact on immune-mediated diseases, and discuss how these insights may translate towards future development of microbiome-targeted therapeutic interventions.
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              Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns.

              M G Dominguez-Bello, E. Costello, M. Contreras … (2010)
              Upon delivery, the neonate is exposed for the first time to a wide array of microbes from a variety of sources, including maternal bacteria. Although prior studies have suggested that delivery mode shapes the microbiota's establishment and, subsequently, its role in child health, most researchers have focused on specific bacterial taxa or on a single body habitat, the gut. Thus, the initiation stage of human microbiome development remains obscure. The goal of the present study was to obtain a community-wide perspective on the influence of delivery mode and body habitat on the neonate's first microbiota. We used multiplexed 16S rRNA gene pyrosequencing to characterize bacterial communities from mothers and their newborn babies, four born vaginally and six born via Cesarean section. Mothers' skin, oral mucosa, and vagina were sampled 1 h before delivery, and neonates' skin, oral mucosa, and nasopharyngeal aspirate were sampled <5 min, and meconium <24 h, after delivery. We found that in direct contrast to the highly differentiated communities of their mothers, neonates harbored bacterial communities that were undifferentiated across multiple body habitats, regardless of delivery mode. Our results also show that vaginally delivered infants acquired bacterial communities resembling their own mother's vaginal microbiota, dominated by Lactobacillus, Prevotella, or Sneathia spp., and C-section infants harbored bacterial communities similar to those found on the skin surface, dominated by Staphylococcus, Corynebacterium, and Propionibacterium spp. These findings establish an important baseline for studies tracking the human microbiome's successional development in different body habitats following different delivery modes, and their associated effects on infant health.
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                Author and article information

                Contributors
                Karin C. Lødrup Carlsen: (View ORCID Profile)
                Cilla Söderhäll: (View ORCID Profile)
                Journal
                Title: Allergy
                Abbreviated Title: Allergy
                Publisher: Wiley
                ISSN (Print): 0105-4538
                ISSN (Electronic): 1398-9995
                Publication date Created: July 2023
                Publication date (Electronic): February 24 2023
                Publication date (Print): July 2023
                Volume: 78
                Issue: 7
                Pages: 1949-1963
                Affiliations
                [1 ] Global Health Institute Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland
                [2 ] Service de Pneumologie, Département de Médecine Centre Hospitalier Universitaire Vaudois (CHUV) Epalinges Switzerland
                [3 ] Department of Dermatology Oslo University Hospital Oslo Norway
                [4 ] Faculty of Medicine Institute of Clinical Medicine, University of Oslo Oslo Norway
                [5 ] Department of Immunology Monash University Melbourne Victoria Australia
                [6 ] Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway
                [7 ] Genetic Unit, Centre for Laboratory Medicine Østfold Hospital Trust Kalnes Norway
                [8 ] Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden
                [9 ] Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden
                [10 ] Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences Ås Norway
                [11 ] Division of Obstetrics and Gynaecology Oslo University Hospital Oslo Norway
                Article
                DOI: 10.1111/all.15671
                PubMed ID: 36779606
                SO-VID: aa59a322-e63f-4db7-9204-4e24f4d45a93
                Copyright © © 2023
                License:

                http://creativecommons.org/licenses/by/4.0/

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