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      Computer Analysis of Oxygen Consumption and Minute Ventilation for the Detection of the Lactate Threshold

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          Abstract

          A group of 15 normal subjects performed a maximal-exercise test on a treadmill. Arterial lactate measurements were related to oxygen consumption (VO<sub>2</sub>) in an exponential fashion (individual correlation coefficients ranged from 0.9 to 0.99). In the same subjects, minute ventilation (VE) was related to VO<sub>2</sub> in an exponential fashion (individual correlation coefficients ranged from 0.98 to 1). There was a close correlation (r = 0.97, p < 0.001) between the slope of the log of lactate versus VO<sub>2</sub> and the slope of the log of VE versus VO<sub>2</sub>. A computer program for predicting the VO<sub>2</sub> corresponding to the accumulation of arterial lactate above the resting normal value (1.3 m M), defined as the lactate threshold, is described. The program is based on the slopes of the exponential relationship between lactate and VO<sub>2</sub> and between VE and VO<sub>2</sub> derived in the normal subjects. The program analyses 30-second values of VO<sub>2</sub> and VE. In 28 subjects, the reproducibility of the lactate threshold prediction was evaluated during two exercise tests 1–7 days apart. The mean predicted VO<sub>2</sub> at the lactate threshold was 18.6 ± 7 ml/(kg·min) during test 1 and during test 2 it was 17.9 ± 7.3 ml/(kg·min); r = 0.91, p < 0.001. The corresponding values for maximal VO<sub>2</sub> were 30.4 ± 13 ml/(kg·min) and 31 ± 13 ml/(kg·min); r = 0.99, p < 0.001. It is concluded that this program offers a reproducible method of determining the lactate threshold during exercise testing employing a frequently used clinical protocol.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1988
          1988
          11 November 2008
          : 75
          : 2
          : 123-132
          Affiliations
          Department of Medicine, Division of Cardiology and Department of Preventive Medicine and Biometrics, University of Colorado, Denver, Colo., USA
          Article
          174359 Cardiology 1988;75:123–132
          10.1159/000174359
          3130988
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Original Paper

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