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      Response of Intrahepatic Vasculature to Isoproterenol and Epinephrine Infusions

      Journal of Vascular Research
      S. Karger AG
      Propranolol, Sotalol, Liver blood flow, Adrenergic receptors, Epinephrine, Isoproterenol

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          Response of hepatic arterial and intrahepatic portal venous vasculature to 10-min infusions of either isoproterenol or epinephrine was studied in 37 in situ dog liver preparations. Isoproterenol infusions at various dose rates (3.06–24.45 µg/min) were given by way of hepatic artery or portal vein. Hepatic arterial vasodilation, which was abolished by propranolol, was clearly evident while response of intrahepatic portal venous bed was incon sistent and not indicative of significant vasodilation. Arterial dilator response was attenuated later in the infusion period when isoproterenol was given at high dose rates. Femoral venous infusions of epinephrine (9.55 µg/min) resulted in a variable and slight hepatic arterial response while portal resistance was consistently increased. Following sotalol, epinephrine produced a marked increase in hepatic artery resistance in every case while intrahepatic portal venous resistance was increased to the same extent as before. It was concluded that both α-receptors (constrictors) and β-receptors (dilators) are present in canine hepatic arterial and mesenteric vessels while intrahepatic portal venous vasculature appears to possess few, if any, β-receptors.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 10
          : 2
          : 65-75
          Department of Physiology, The Ohio State University College of Medicine, Columbus, Ohio
          157961 Angiologica 1973;10:65–75
          © 1973 S. Karger AG, Basel

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          Page count
          Pages: 11

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Adrenergic receptors,Isoproterenol,Epinephrine,Liver blood flow,Propranolol,Sotalol


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