Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Response of Intrahepatic Vasculature to Isoproterenol and Epinephrine Infusions

      Journal of Vascular Research

      S. Karger AG

      Propranolol, Sotalol, Liver blood flow, Adrenergic receptors, Epinephrine, Isoproterenol

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Response of hepatic arterial and intrahepatic portal venous vasculature to 10-min infusions of either isoproterenol or epinephrine was studied in 37 in situ dog liver preparations. Isoproterenol infusions at various dose rates (3.06–24.45 µg/min) were given by way of hepatic artery or portal vein. Hepatic arterial vasodilation, which was abolished by propranolol, was clearly evident while response of intrahepatic portal venous bed was incon sistent and not indicative of significant vasodilation. Arterial dilator response was attenuated later in the infusion period when isoproterenol was given at high dose rates. Femoral venous infusions of epinephrine (9.55 µg/min) resulted in a variable and slight hepatic arterial response while portal resistance was consistently increased. Following sotalol, epinephrine produced a marked increase in hepatic artery resistance in every case while intrahepatic portal venous resistance was increased to the same extent as before. It was concluded that both α-receptors (constrictors) and β-receptors (dilators) are present in canine hepatic arterial and mesenteric vessels while intrahepatic portal venous vasculature appears to possess few, if any, β-receptors.

          Related collections

          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1973
          1973
          18 September 2008
          : 10
          : 2
          : 65-75
          Affiliations
          Department of Physiology, The Ohio State University College of Medicine, Columbus, Ohio
          Article
          157961 Angiologica 1973;10:65–75
          10.1159/000157961
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Paper

          Comments

          Comment on this article