The prevalence of 
Helicobacter
pylori is decreasing in Iranian patients

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Abstract

Aim:

The objective of this study was to evaluate the time trend of Helicobacter pylori ( H. pylori) prevalence and presence of intestinal Metaplasia over the period of seven years among gastritis Iranian patients.

Background:

H. pylori is the major causal factor in chronic gastritis. Its acquisition leads to a chronic, usually lifelong, inflammation of the gastric mucosa, which may gradually progress to atrophy with intestinal metaplasia in a significant proportion of infected individuals.

Patients and methods:

H. pylori and intestinal Metaplasia data among 14,860 consecutive gastritis patients, who referred to the gastrointestinal department of Tehran’s Taleghani Hospital in Iran from 2008 to 2014, was examined by sex and age group. The patients were divided into six age groups (16-30, 30-40, 40-50, 50-60 and >70). The chi-square test was used to compare the qualitative variables.

Results:

The overall prevalence rate among patient with H. pylori infection was 83.5% (12406/14860) and 11,394 (84.1%) of them were related to the gastritis. The prevalence rate of H . pylori among patient with severe gastritis was significantly higher ( P<0.05) compared to mild and moderate gastritis. In addition, the prevalence of H . pylori decreased with age and has been declined in recent years. The presence of intestinal metaplasia increased with age ( P<0.05).

Conclusion:

The results of this study showed that the prevalence of H . pylori infection in Iranian population has been declined in recent years; nevertheless it seems to be highly prevalent in Iran. We also find a significant positive relationship between H . pylori infection and gastritis. There is no association between sex and infection, however in contrast with the most studies its prevalence decreased with age.

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Most cited references 40

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Review article: natural history and epidemiology of Helicobacter pylori infection.

M F Go (2002)

Helicobacter pylori is a common bacterium infecting about half the world's population. It is causally linked with a diverse spectrum of gastrointestinal clinical disorders including peptic ulcer disease, gastric cancer, and gastric MALT lymphoma. The principal reservoir is the human stomach, and transmission probably occurs by person-to-person passage. Prevalence rates are generally much higher in developing countries compared to developed countries, although there are subgroups within many regions with higher H. pylori prevalence than in the general population. The prevalence of H. pylori varies by geographical location, ethnic background, socioeconomic conditions, and age. Recent studies suggest decreasing prevalence in developed countries or those with rapidly improving socioeconomic conditions. Comparative studies of the two fully sequenced H. pylori genomes are providing understanding of its large genetic diversity and bacterial virulence factors. The discovery of the type IV secretion system in H. pylori and its role in translocation of the CagA protein from the bacterial cell into the host epithelial cell provides insight into how host-bacterial interaction may lead to host disease. Cytokine promoter polymorphisms are determinants important in host gastric acid secretion status. Understanding the changing trends in H. pylori epidemiology, details of its transmission pathways, and the bacterial and host determinants leading to gastroduodenal disease remain the challenges in this area. Global epidemiological studies, advances in technology, and medical interventions have converged to help clarify the mechanisms of interaction between this ubiquitous micro-organism and its host that result in its diverse clinical manifestations.

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Seroprevalence of Helicobacter pylori in South Korea.

Jeong Yoon Yim, Nayoung Kim, Seung Choi … (2007)

Helicobacter pylori-associated gastrointestinal diseases have been widely recognized. The aims of this study were to investigate the interval change of seropositivity of H. pylori between 1998 and 2005 in Korean adult population and to find the factors related to H. pylori infection. Between January and December of 2005, a total of 15,916 health check-up subjects (aged > or = 16 years) from all parts of South Korea responded to the questionnaire, and the prevalence of H. pylori was investigated by measuring anti-H pylori IgG antibodies. The seropositivity in asymptomatic subjects (aged > or = 16 years) was compared with that of 1998, which was surveyed by the Korean H. pylori Study Group. The overall seropositivity rate (aged > or = 16 years) was 56.0%, and 13.9% of seropositive subjects were found to have a history of H. pylori eradication therapy. With the exclusion of subjects who had a history of H. pylori eradication and current gastrointestinal symptoms, the seropositivity rate of H. pylori became 59.6% in 8020 subjects. Seroprevalence of H. pylori was significantly higher in subjects aged 50-59 years, males, low income group, and subjects from provinces. The seroprevalence in 2005 (59.6%) significantly decreased compared with that of 1998 (66.9%), and the decrease was significant in subjects aged < 70 years, Seoul and Gyeonggi province (which is close to Seoul). The seroprevalence of H. pylori in asymptomatic health check-up adult subjects in 2005 decreased to 59.6% from 66.9% in 1998, probably as a result of the improvement of socioeconomic status and hygiene.

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Age-specific incidence of Helicobacter pylori.

Marion Rowland, Leslie Daly, Marian Vaughan … (2006)

Helicobacter pylori is most likely acquired in childhood, but the incidence of infection has not been determined prospectively by using an appropriate noninvasive test. The aim of this study was to determine the age-specific incidence of Helicobacter pylori infection in children and the risk factors for infection. Three hundred twenty-seven healthy index children between 24 and 48 months of age were enrolled over 15 months. At baseline, the Helicobacter pylori infection status of each index child and his or her older siblings and parents was assessed by using the carbon 13-urea breath test. All noninfected index children were then followed up with an annual carbon 13-urea breath test for 4 years to determine whether they became infected with Helicobacter pylori and, if so, the age at first infection. Information on potential risk factors was collected at baseline and each subsequent visit. At baseline assessment, 28 of 327 (8.6%) index children were infected with Helicobacter pylori. The mean age of the 28 infected children was 32.78 months (SD, 5.14 months). Over the next 4 years, 279 index children not infected at baseline contributed 970 person-years of follow-up to the study. During this time, 20 children became infected with Helicobacter pylori. The rate of infection per 100 person-years of follow-up was highest in the 2-3-year age group (5.05 per 100 person-years of follow-up (95% confidence interval, 1.64-11.78) and declined progressively as children aged. Only 1 child became infected after 5 years of age. Having an infected mother, an infected older sibling, and delayed weaning from a feeding bottle (ie, after 24 months of age) were all risk factors for infection. Children who become infected with Helicobacter pylori are infected at a very young age, and the risk of infection declines rapidly after 5 years of age. These findings have important implications for studies on the mode of transmission of infection.

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Author and article information

Journal

Journal ID (nlm-ta): Gastroenterol Hepatol Bed Bench

Journal ID (iso-abbrev): Gastroenterol Hepatol Bed Bench

Journal ID (publisher-id): GHFBB

Title: Gastroenterology and Hepatology From Bed to Bench

Publisher: Shaheed Beheshti University of Medical Sciences (Tehran, Iran )

ISSN (Print): 2008-2258

ISSN (Electronic): 2008-4234

Publication date (Print): Spring 2015

Volume: 8

Issue: Suppl1

Pages: S23-S29

Affiliations

[1 ] Gastroenterology and Liver Disease Research center, Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran

[2 ] Department of Biostatistics, Shahid Beheshti University of Medical Science, Tehran, Iran

Author notes

Reprint or Correspondence: Mohamad Amin Pourhoseingholi, PhD. Gastroenterology and Liver Disease Research center, Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Science, Tehran, Iran. E-mail: amin_phg@yahoo.com

Article

Publisher ID: GHFBB-8-S23

PMC ID: 4495420

PubMed ID: 26171134

SO-VID: ab0a0ac0-3706-45dd-8107-29a9605b54c2

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The prevalence of Helicobacter pylori is decreasing in Iranian patients

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Abstract

Aim:

Background:

Patients and methods:

Results:

Conclusion:

Related collections

When did Helicobacter first colonise humans?

Most cited references 40

Review article: natural history and epidemiology of Helicobacter pylori infection.

Seroprevalence of Helicobacter pylori in South Korea.

Age-specific incidence of Helicobacter pylori.

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