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      Triennial Report of Endocrinology and Metabolism, 2015 to 2017

      editorial
      , ,
      Endocrinology and Metabolism
      Korean Endocrine Society

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          Abstract

          INTRODUCTION Endocrinology and Metabolism (EnM) is entering its 6th year after its conversion into a fully English journal in 2013. Since then, EnM has experienced enormous growth in the number of submissions of original articles, the number of articles from countries other than South Korea, and the number of citations and accesses from readers all over the world. In our opinion, EnM is publishing top-quality articles, and we are proud that these excellent articles are being cited increasingly often. EnM is now indexed in KoreaMed, the Korean Medical Citation Index (KoMCI), KoreaMed Synapse, the Korea Citation Index (KCI), ScienceCentral, PubMed, PubMed Central, Scopus, EBSCO, Embase, DOI/Crossref, the Chemical Abstracts Service (CAS), the Directory of Open Access Journals (DOAJ), and Google Scholar. EnM has been indexed in the Emerging Sources Citation Index (ESCI), which is a new database of Clarivate Analytics (Philadelphia, PA, USA), and we are anticipating its inclusion in Science Citation Index Expanded (SCIE) in the very near future. Prof. Won-Young Lee, the Editor-in-Chief of EnM, published an editorial on the indexing of EnM in ESCI last year [1]. In this report, the editorial office of EnM proudly presents our achievements and our efforts to improve EnM during the last 3 years, from 2015 to 2017. MANUSCRIPT FLOW (2015 TO 2017) During the 2015 to 2017 period, EnM processed 208 first-time submissions (Fig. 1). This represents an increase of around 50% from the previous period, 2013 to 2014. Among the papers submitted to EnM during this period, 47% were from countries outside Korea. It is essential for top-tier journals to completely process submitted manuscripts in a reasonable time. In addition, the editorial office should always present appropriate reasons for accepting or rejecting a submission. The mean time from submission to acceptance or rejection of the manuscripts submitted to EnM is shown in Table 1. On average, it took only 13.1 to 8.2 weeks after submission to EnM for a manuscript to be accepted or rejected. This is a 33% shorter time period than the interval in the previous period (2013 to 2014). Two factors might have reduced the time required for a decision regarding acceptance to be made. First, the decision to reject or review a submitted manuscript is made as quickly as possible after its submission by the three deputy editors in their areas of expertise and finally by the Editor-in-Chief. The rapid decision by the editorial board of EnM to reject or review a submission likely helped shorten the processing time. The second factor contributing to the short processing interval is our short review period. We ask reviewers to review our manuscripts within 2 weeks, and thankfully, most of the review reports were submitted by the reviewers within the requested time frame. Fig. 2 shows the acceptance and rejection rates of the submitted manuscripts. The rejection rate reaches 40% in this period. The rejection rate increased by 65% compared to the previous period (2013 to 2014). Table 2 shows the number and the distribution of the types of articles published in EnM during the period. Starting on September 1, 2015, EnM stopped accepting case reports, in accordance with the current trend to separate journals that publish original articles from journals that only publish case reports. As EnM focuses on publishing original articles, the editorial office decided not to publish case reports. The decreasing trend in the total number of yearly published articles might have been due to the decision not to publish case reports. ANALYSIS OF EnM CITATIONS FROM THE WEB OF SCIENCE CORE COLLECTION We periodically analyze the citations of articles published in EnM within the Web of Science. The number of citations of EnM articles from the Web of Science is rapidly increasing (Fig. 3). EnM was only cited three times in 2013; however, in 2017, the total number of citations increased to 419, which is more than a 100-fold increase in citations compared to 4 years ago. This is extremely rapid progress in terms of citations and popularity, and this trend confirms that many researchers are interested in our journal and are citing our articles in their research papers. We suggest that several reasons may explain this rapid increase in citations of EnM. First, EnM covers a broad range of topics within endocrinology and metabolism, from the molecular basis of endocrine diseases to clinical practices—that is, from bench to bedside. By regularly following issues of EnM, readers can expand their knowledge base in the field of endocrinology and metabolism. Second, more and more world-renowned experts in the field of endocrinology and metabolism are interested in EnM and are writing review articles to be published in EnM. We believe that the reputation of EnM as a globally leading endocrinology journal and as the leading endocrinology journal in the Asia-Pacific region has spread to researchers throughout the world, thanks to our authors who publish high-quality research in EnM. Distinguished international researchers who are already experts in their fields are willing to contribute review articles to EnM. We also think that the reputation of the Korean Endocrine Society (KES) has contributed to the success of EnM, since EnM has grown hand in hand with the Seoul International Congress of Endocrinology and Metabolism, the official annual meeting of KES, which is a world-leading annual congress in this field. Finally, the quality and standards of research papers submitted to EnM are high, which maintains and improves the reputation of EnM as time goes by. We have analyzed the number of citations of all articles published in EnM using the ‘cited by’ tool. The most-cited articles published in EnM from 2015 to 2016 are presented in Table 3. The number of citations of these articles is fairly high, even within a relatively short period of observation, which is further proof of the high quality of the articles published in EnM. In addition, the high quality and standards of EnM represent the high-quality research done by Korean researchers in the field of endocrinology and metabolism. Fig. 4 shows the distribution of the countries of articles that cited EnM from 2015 to 2017. Most of the citations of EnM were from outside of Korea, which is an astonishing testament to the successful internationalization of EnM. DEMOGRAPHICS OF AUTHORS WHO SUBMITTED OR PUBLISHED ARTICLES IN EnM Table 4 (Fig. 5) shows the distribution of the countries of submitting authors. The authors who submitted their articles to EnM were from 30 countries, including South Korea. The Philippines, United States, and India were the top three countries (except South Korea) from which manuscripts were submitted to EnM. As can be seen, manuscripts are submitted to EnM from all over the world, not just a single continent. Fig. 6 shows the distribution of countries of the manuscripts that were finally accepted for publication in EnM. The countries of the accepted articles show a similar worldwide distribution to that of the countries of the submitted articles. CONTENT OF THE ARTICLES PUBLISHED IN EnM EnM covers all areas in the field of endocrinology and metabolism. The proportions of the content areas of the articles published in EnM are shown in Fig. 7. The most popular area from 2015 to 2017 was diabetes, comprising 29% of all published articles, followed by thyroid disease, with 24% of all published articles. This trend has remained somewhat consistent since 2013; however, an increasing number of articles in the field of thyroid disease are being submitted and published. Even though the articles published in EnM are being read and cited by researchers throughout the world, as seen by the rapidly increasing citation numbers described above, EnM has made an effort to publish especially high-quality articles, such as randomized controlled studies, research using big data (such as nationwide population-based studies), and meta-analyses (Table 5). We published two meta-analyses in this issue [2 3]. We have also published two papers regarding the medical costs of endocrine diseases that could be useful for stakeholders and policy-makers in government [4 5]. Many papers based on nationwide population-based studies are also being submitted and published, and these articles may also influence the development of governmental policies and guidelines (Table 5). More and more high-quality papers are being published in EnM, and we expect that these papers will have an impact on society and government. PUBLICATION AND RESEARCH ETHICS Our journal follows the ethical guidelines specified in the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals established by the International Committee of Medical Journal Editors [6]. Regarding the disclosure of conflicts of interest, we strongly recommend that authors state any financial support associated with the study, including stocks or consultation arrangements with pharmaceutical companies, as well as any political pressure from special interest groups or academia-related issues at the end of the text, under a subheading entitled “CONFLICTS OF INTEREST.” We also emphasize the importance of obtaining approval from an authorized review board for the research protocol or process in order to exclude any ethical problems that might violate current standards. Human studies must conform to current ethical standards and should be approved by the appropriate Institutional Review Board (IRB), and we strongly recommend that authors place a statement concerning IRB approval at the beginning of the methods section. We also emphasize the importance of human rights and informed consent in every study that might need informed consent from its participants. This category includes epidemiologic studies using human data, as well as any studies that use potentially personally identifiable or sensitive data or images. Authors may be questioned about the details of consent forms or the consent process, and the informed consent process should be clearly described in the text of the manuscript. CONCLUSIONS We have briefly presented the achievements that we have accomplished during the 2015 to 2017 period. EnM is already indexed in ESCI, and is headed towards inclusion in SCIE in the near future. All the articles published in EnM are open-access and can be read by all readers throughout the world. There are no submission fees or page charges. As editors, we are open to any helpful advice or comments on the growth and advancement of EnM. We will make every effort for EnM to become a globally top-tier journal in the field of endocrinology and metabolism. As you have read in this editorial, EnM is moving forward at a rapid pace and continually breaking its own records. We believe that the most important aspects of a good journal are to publish excellent research and to be friendly and approachable to its readers and authors. EnM will always try its best to be unbeatable in quality and accessibility. Please visit us at https://e-enm.org, or search for EnM articles of interest to you. We would like to express our sincere appreciation to our readers.

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          Cost-of-Illness Trends Associated with Thyroid Disease in Korea

          Background The purpose of this study is to analyze the scale of and trends associated with the cost-of-illness of thyroid disease in Korea at 2-year intervals during the last 10 years for which data are available. Methods Cost-of-illness was estimated in terms of direct and indirect costs. Direct costs include direct medical costs due to hospitalization, outpatient and pharmacy sectors, transportation, and care-giver costs. Indirect costs include future income loss due to premature death and loss of productivity as a result of absence from work. Results The cost-of-illness of thyroid disease in Korea was estimated at 224.2 billion won in 2002, 303.4 billion won in 2004, 400.3 billion won in 2006, 570.4 billion won in 2008, and 762.2 billion won in 2010. For example, the cost-of-illness of thyroid disease in 2010 was 3.4 times greater compared to 2002. The direct cost of the total cost-of-illness was 69.7%, which accounted for the highest proportion of costs. Cost-of-illness for individuals between the ages of 30 and 50 accounted for the greatest share of costs. Conclusion The cost-of-illness of thyroid disease was relatively large in economically active age groups, and demonstrated a very rapid growth rate compared to other major diseases in Korea. Therefore, we suggest nationwide recognition of the importance of prevention and management of thyroid disease and prioritization of the management of thyroid disease among current and future health promotion policies in Korea.
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            Procalcitonin as Marker of Recurrent Medullary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

            Background Calcitonin measurement is pivotal in the management of medullary thyroid carcinoma (MTC), but several pitfalls can affect its reliability. Other potential markers have been proposed, and procalcitonin (ProCT) has been reported as promising. The present study was undertaken to summarize the published data and provide more robust estimates on the reliability of ProCT as marker in the management of patients with MTC. Methods The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The sources comprised studies published through May 2018. Original articles that reported series of MTC patients undergone ProCT during postoperative follow-up were searched. A random-effects model was used for statistical pooling of the data. The I 2 index was used to quantify the consistency among the studies. The Egger test evaluated the possible presence of significant publication bias. Quality assessment of the studies was performed according to Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). Results According to inclusion and exclusion criteria five papers, reporting 296 MTC patients undergone ProCT evaluation, were finally selected. The number of MTC with recurrence was 140. The pooled sensitivity of ProCT in detecting recurrence was 96% (95% confidence interval [CI], 92% to 99%), with neither heterogeneity (I 2=0%) nor publication bias (Egger test, 3.16; P=0.99). The pooled specificity was 96% (95% CI, 87% to 100%) with mild heterogeneity (I 2=66.6%), while Egger test was not calculable. Conclusion The present meta-analysis provides evidence that ProCT is reliable to manage MTC patients during their postoperative follow-up.
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              Economic Evaluation of Recombinant Human Thyroid Stimulating Hormone Stimulation vs. Thyroid Hormone Withdrawal Prior to Radioiodine Ablation for Thyroid Cancer: The Korean Perspective

              Background Previous studies have suggested that recombinant human thyroid stimulating hormone (rhTSH) stimulation is an acceptable alternative to thyroid hormone withdrawal (THW) when radioiodine remnant ablation is planned for thyroid cancer treatment, based on superior short-term quality of life with non-inferior remnant ablation efficacy. This study evaluated the cost-effectiveness of radioiodine remnant ablation using rhTSH, compared with the traditional preparation method which renders patients hypothyroid by THW, in Korean perspective. Methods This economic evaluation considered the costs and benefits to the Korean public healthcare system. Clinical experts were surveyed regarding the current practice of radioiodine ablation in Korea and their responses helped inform assumptions used in a cost effectiveness model. Markov modelling with 17 weekly cycles was used to assess the incremental costs per quality-adjusted life year (QALY) associated with rhTSH. Clinical inputs were based on a multi-center, randomized controlled trial comparing remnant ablation success after rhTSH preparation with THW. The additional costs associated with rhTSH were considered relative to the clinical benefits and cost offsets. Results The additional benefits of rhTSH (0.036 QALY) are achieved with an additional cost of Korean won ₩961,105, equating to cost per QALY of ₩26,697,361. Sensitivity analyses had only a modest impact upon cost-effectiveness, with one-way sensitivity results of approximately ₩33,000,000/QALY. Conclusion The use of rhTSH is a cost-effective alternative to endogenous hypothyroid stimulation prior to radioiodine ablation for patients who have undergone thyroidectomy in Korea.
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                Author and article information

                Contributors
                Role: Deputy Editor of Endocrinology and Metabolism
                Role: Managing Editor of Endocrinology and Metabolism
                Role: Editor-in-Chief of Endocrinology and Metabolism
                Journal
                Endocrinol Metab (Seoul)
                Endocrinol Metab (Seoul)
                ENM
                Endocrinology and Metabolism
                Korean Endocrine Society
                2093-596X
                2093-5978
                June 2018
                21 June 2018
                : 33
                : 2
                : 195-201
                Author notes
                Corresponding author: Won-Young Lee. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea. Tel: +82-2-2001-2579, Fax: +82-2-2001-2049, drlwy@ 123456hanmail.net
                Author information
                https://orcid.org/0000-0002-6108-7758
                https://orcid.org/0000-0002-7655-2771
                https://orcid.org/0000-0002-1082-7592
                Article
                10.3803/EnM.2018.33.2.195
                6021320
                29947176
                aba52692-72be-4141-8848-de36d8ae58e3
                Copyright © 2018 Korean Endocrine Society

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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