Contributors
Shinya Eto: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: ValidationRole:
VisualizationRole: Writing – original draft
Mizuki Goto: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Minami Soga: Role: Formal analysisRole: SupervisionRole: ValidationRole: Writing – review & editing
Yumi Kaneko: Role: Data curation
Yusuke Uehara: Role: Data curationRole: Formal analysisRole: Investigation
Hiroshi Mizuta: Role: Supervision
Takumi Era:
ORCID: http://orcid.org/0000-0003-2693-1914
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Johnson Rajasingh: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
25
July
2018
Publication date Collection: 2018
Volume: 13
Issue: 7
Electronic Location Identifier: e0200790
Affiliations
[1
]
Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto
University, Kumamoto, Japan
[2
]
Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan
[3
]
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kumamoto University,
Kumamoto, Japan
University of Kansas Medical Center, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-02372
DOI: 10.1371/journal.pone.0200790
PMC ID: 6059447
PubMed ID: 30044827
SO-VID: ad78ca8b-8c9a-4ad5-9981-410312b4626f
Copyright © © 2018 Eto et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 23
January
2018
Date
accepted
: 3
July
2018
Page count
Figures: 7,
Tables: 0,
Pages: 22
Funding
Funded by: Japan Society for the Promotion Science (JSPS) program on Strategic Young Researcher
Overseas Visits Program for Accelerating Brain Circulation
Award ID: S2803
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
Funded by: The Ministry of Health, Labor, and Welfare of Japan
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
Funded by: The Japan Agency for Medical Research and Development (A-MED)
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
Funded by: Core Research for Evolutional Science and Technology (CREST)
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
Funded by: Grant-in-Aid for Scientific Research (KAKENHI C)
Award ID: 25505002 and 18K06264
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
Funded by: The Japan Science and Technology Agency (JST)
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2693-1914
Takumi Era
This study was supported, in part, by grants from Japan Society for the Promotion
Science (JSPS, URLs:
http://www.jsps.go.jp/english/) program on Strategic Young Researcher Overseas Visits Program for Accelerating Brain
Circulation (Grant Number S2803), the Ministry of Health, Labor, and Welfare of Japan
(URLs:
http://www.mhlw.go.jp/english/), the Japan Agency for Medical Research and Development (A-MED, URLs:
https://www.amed.go.jp/en/), Core Research for Evolutional Science and Technology (CREST, URLs:
https://www.jst.go.jp/kisoken/crest/en/), Grant-in-Aid for Scientific Research (KAKENHI C, 25505002 and 18K06264, URLs:
https://www.jsps.go.jp/english/e-grants/) and the Japan Science and Technology Agency (JST, URLs:
https://www.jst.go.jp/EN/). T.E. received all of above grants. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Stem Cells
Subject:
Mesenchymal Stem Cells
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Cell Differentiation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Ulcers
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Ulcers
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Tissue Repair
Subject:
Wound Healing
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Tissue Repair
Subject:
Wound Healing
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Medicine and Health Sciences
Subject:
Rheumatology
Subject:
Arthritis
Subject:
Osteoarthritis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Chondrocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Chondrocytes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
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