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Cyclosporin A protects against ischemia-reperfusion injury in the brain
November 1992
November 1992
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Abstract
We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion
injury in the brain using a transient focal ischemia model in rats. In CsA-treated
rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex
perfused by the middle cerebral artery (MCA) and infarct size were decreased compared
with those in olive oil treated control rats. These results suggest that CsA is beneficial
in reducing ischemia-reperfusion injury, possibly by the suppression of immunological
reactions.