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Abstract
Background
Renal resistive index (RI) and pulsatility index (PI) are reliable measures of downstream
renal resistance which correlate with the severity of renal disease. To date, MR phase
velocity mapping studies have lacked the temporal resolution required to determine
these pulsatility parameters. Our aim is to develop a high temporal resolution breath-hold
spiral phase velocity mapping technique for assessment of the temporal flow patterns
in renal arteries and to determine inter-study reproducibility.
Methods
An interleaved spiral phase velocity mapping sequence was developed on a 3T Skyra
scanner (Siemens) using 1-1 water excitation and with full k-space coverage in 8 spiral
interleaves of 12 ms duration. Phase map subtraction of datasets with symmetric bi-polar
velocity encoding gradients resulted in velocity maps with a through-plane phase sensitivity
of +/- 150cm/s. Retrospectively ECG gated data were acquired in a 17 cardiac cycle
breath-hold (includes 1 dummy cycle) with a spatial resolution of 1.4 x 1.4 mm (reconstructed
to 0.7 x 0.7 mm) and a repeat time of 19 ms. Renal artery velocity maps were acquired
in 10 healthy volunteers (10 left and 10 right arteries). Data were acquired in each
of two separate scanning sessions with the volunteer leaving the scanner between sessions.
For each acquisition (40 in total), RI and PI were calculated by 2 observers as follows:
RI = (PSV - MDV) / PSV
PI = (PSV - MDV) / MV
where PSV = peak systolic velocity, MDV = minimum diastolic velocity and MV = mean
velocity through the cardiac cycle
Background phase errors were determined from (i) a large stationary phantom acquisition
and (ii) by fitting a background phase map to user defined stationary points in the
inter-vertebral disks. Inter-observer and inter-study reproducibility of RI, PI and
renal artery blood flow (RABF) per kidney were determined as the mean (+/- standard
deviation) of the paired differences between observers and between scanning sessions
and by the intraclass correlation coefficient (ICC).
Results
Figure 1 shows example data. RI, PI and RABF per kidney were 0.71+/- 0.06, 1.47 +/-
0.29 and 413 +/- 122 ml/min respectively. Inter-observer and inter-study Bland Alman
plots are shown in Figure 2. The inter-study reproducibilities were: RI -0.00 +/-
0.04 , PI -0.03 +/- 0.17, and RABF per kidney 17.9 +/- 44.8 ml/min. Inter-study ICCs
(observers 1 and 2 respectively) were 0.87 and 0.86 (RI), 0.92 and 0.93 (PI) and 0.96
and 0.95 (RABF). The effect of background phase correction was negligible (<2% for
each parameter).
Figure 1
Example pilot scans showing the proximal renal arteries (a) together with systolic
magnitude images and velocity maps in the initial and repeat scanning sessions and
the temporal patterns of flow velocity through the cardiac cycle for the proximal
right (solid arrows) (b) and left (open arrows) (c) renal arteries respectively.
Figure 2
Inter-observer (a) and inter-study (b) Bland Altman plots of RI (resistive index),
PI (pulsatility index) and RABF (renal artery blood flow) per kidney in 10 healthy
volunteers. For each plot, the horizontal lines show the mean difference and the 95%
limits of agreement (mean +/- 2SD) between observers (a) or between scanning sessions
(b).
Conclusions
High temporal resolution breath-hold spiral phase velocity mapping allows reproducible
assessment of renal pulsatility indices and RABF. We conclude that this technique
is suitable for studying temporal flow velocity patterns in the renal arteries.
Funding
N/A.
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