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      A new method to estimate mortality in crisis-affected and resource-poor settings: validation study

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          Abstract

          Background Data on mortality rates are crucial to guide health interventions in crisis-affected and resource-poor settings. The methods currently available to collect mortality data in such settings feature important methodological limitations. We developed and validated a new method to provide near real-time mortality estimates in such settings.

          Methods We selected four study sites: Kabul, Afghanistan; Mae La refugee camp, Thailand; Chiradzulu District, Malawi; and Lugufu and Mtabila refugee camps, Tanzania. We recorded information about all deaths in a 60-day period by asking key community informants and decedents’ next of kin to refer interviewers to bereaved households. We used the total number of deaths and population estimates to calculate mortality rates for 60- and 30-day periods. For validation we compared these rates with a best estimate of mortality using capture–recapture analysis with two further independent lists of deaths.

          Results The population covered by the new method was 76 476 persons in Kabul, 43 794 in Mae La camp, 54 418 in Chiradzulu District and 80 136 in the Tanzania camps. The informant method showed moderate sensitivity (55.0% in Kabul, 64.0% in Mae La, 72.5% in Chiradzulu and 67.7% in Tanzania), but performed better than the active surveillance system in the Tanzania refugee camps.

          Conclusions The informant method currently features moderate sensitivity for accurately assessing mortality, but warrants further development, particularly considering its advantages over current options (ease of implementation and analysis and near-real estimates of mortality rates). Strategies should be tested to improve the performance of the informant method.

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          Most cited references35

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          Where giving birth is a forecast of death: maternal mortality in four districts of Afghanistan, 1999-2002.

          Maternal mortality in Afghanistan is uniformly identified as an issue of primary public-health importance. To guide the implementation of reproductive-health services, we examined the numbers, causes, and preventable factors for maternal deaths among women in four districts. We did a retrospective cohort study of women of reproductive age (15-49 years) who died between March 21, 1999, and March 21, 2002, in four selected districts in four provinces: Kabul city, Kabul province (urban); Alisheng district, Laghman province (semirural); Maywand, Kandahar province (rural); and Ragh, Badakshan province (rural, most remote). Deaths among women of reproductive age were identified through a survey of all households in randomly selected villages and investigated through verbal-autopsy interviews of family members. In a population of 90 816, 357 women of reproductive age died; 154 deaths were related to complications during pregnancy, childbirth, or the puerperal period. Most maternal deaths were caused by ante-partum haemorrhage, except in Ragh, where a greater proportion of women died of obstructed labour. All measures of maternal risk were high, especially in the more remote areas; the maternal mortality ratio (per 100,000 livebirths) was 418 (235-602) in Kabul, 774 (433-1115) in Alisheng, 2182 (1451-2913) in Maywand, and 6507 (5026-7988) in Ragh. In the two rural sites, no woman who died was assisted by a skilled birth attendant. Maternal mortality in Afghanistan is high and becomes significantly greater with increasing remoteness. Deaths could be averted if complications were prevented through optimisation of general health status and if complications that occurred were treated to reduce their severity--efforts that require a multisectoral approach to increase availability and accessibility of health care.
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            Capture-recapture and multiple-record systems estimation I: History and theoretical development. International Working Group for Disease Monitoring and Forecasting.

            This paper reviews the historical background and the theoretical development of models for the analysis of data from capture-recapture or multiple-record systems for estimating the size of closed populations. The models and methods were originally developed for use in fisheries and wildlife biology and were later adapted for use in connection with human populations. Application to epidemiology came much later. The simplest capture-recapture model involves two lists or samples and has four key assumptions: that the population is closed, that individuals can be matched from capture to recapture, that capture in the second sample is independent of capture in the first sample, and that the capture probabilities are homogeneous across all individuals in the population. Log-linear models provide a convenient representation for this basic capture-recapture model and its extensions to K lists. The paper provides an overview for these models and illustrates how they allow for dependency among the lists and heterogeneity in the population. The use of log-linear models for estimation in the presence of both dependence and heterogeneity is illustrated on a four-list example involving ascertainment of diabetes using data gathered in 1988 from residents of Casale Monferrato, Italy. The final section of the paper discusses techniques for model selection in the context of models for estimating the size of populations.
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              Violence-related mortality in Iraq from 2002 to 2006.

              Estimates of the death toll in Iraq from the time of the U.S.-led invasion in March 2003 until June 2006 have ranged from 47,668 (from the Iraq Body Count) to 601,027 (from a national survey). Results from the Iraq Family Health Survey (IFHS), which was conducted in 2006 and 2007, provide new evidence on mortality in Iraq. The IFHS is a nationally representative survey of 9345 households that collected information on deaths in the household since June 2001. We used multiple methods for estimating the level of underreporting and compared reported rates of death with those from other sources. Interviewers visited 89.4% of 1086 household clusters during the study period; the household response rate was 96.2%. From January 2002 through June 2006, there were 1325 reported deaths. After adjustment for missing clusters, the overall rate of death per 1000 person-years was 5.31 (95% confidence interval [CI], 4.89 to 5.77); the estimated rate of violence-related death was 1.09 (95% CI, 0.81 to 1.50). When underreporting was taken into account, the rate of violence-related death was estimated to be 1.67 (95% uncertainty range, 1.24 to 2.30). This rate translates into an estimated number of violent deaths of 151,000 (95% uncertainty range, 104,000 to 223,000) from March 2003 through June 2006. Violence is a leading cause of death for Iraqi adults and was the main cause of death in men between the ages of 15 and 59 years during the first 3 years after the 2003 invasion. Although the estimated range is substantially lower than a recent survey-based estimate, it nonetheless points to a massive death toll, only one of the many health and human consequences of an ongoing humanitarian crisis. Copyright 2008 Massachusetts Medical Society.
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                Author and article information

                Journal
                Int J Epidemiol
                ije
                intjepid
                International Journal of Epidemiology
                Oxford University Press
                0300-5771
                1464-3685
                December 2010
                1 November 2010
                1 November 2010
                : 39
                : 6
                : 1584-1596
                Affiliations
                1Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK, 2United States Centers for Disease Control and Prevention, Atlanta, GA, USA, 3Médecins Sans Frontières France, Malawi Programme, Chiradzulu, Malawi, 4United Nations High Commissioner for Refugees, Tanzania Office, Kigoma, Tanzania, 5Brixton Health, Plymouth, UK and 6Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
                Author notes
                *Corresponding author. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. E-mail: francesco.checchi@ 123456lshtm.ac.uk
                Article
                dyq188
                10.1093/ije/dyq188
                2992632
                21044978
                aec19a0f-fddc-4049-9a9c-c36e0af3b7a0
                Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2010; all rights reserved.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 9 September 2010
                Categories
                Methodology

                Public health
                mortality,crisis,validation,death rate,humanitarian,capture–recapture,survey,surveillance
                Public health
                mortality, crisis, validation, death rate, humanitarian, capture–recapture, survey, surveillance

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