CD19(+)IL-10(+) regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4(+) T cells to CD4(+)Foxp3(+) regulatory T cells.

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Abstract

Increase of regulatory T cells (Tregs) in the tumor microenvironment predicts worse survival of patients with various types of cancer including tongue squamous cell carcinoma (TSCC). Recently, the cross-talk between Tregs and regulatory B cells (Bregs) has been shown in several tumor models. However the relevance of Bregs to tumor immunity in humans remains elusive. Our objective was to investigate the distribution and function of Bregs in TSCC microenvironment.

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Journal

Journal ID (iso-abbrev): Oral Oncol.

Title: Oral oncology

Publisher: Elsevier BV

ISSN (Electronic): 1879-0593

ISSN (Print): 1368-8375

Publication date (Electronic): Feb 2016

Volume: 53

Affiliations

[1 ] Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory, Sun Yat-Sen University, Guangzhou, China.

[2 ] Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

[3 ] Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory, Sun Yat-Sen University, Guangzhou, China. Electronic address: yujie0350@126.com.

[4 ] Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory, Sun Yat-Sen University, Guangzhou, China. Electronic address: drliaoguiqing@hotmail.com.

Article

Publisher Item ID: S1368-8375(15)00369-3

DOI: 10.1016/j.oraloncology.2015.11.003

PubMed ID: 26631955

SO-VID: af1edf5d-1d53-4b59-a7a2-9da67fd7000b

History

Keywords: Bregs,CD40L,Double staining,IL-10,Immunosuppression,Oral oncology,Tongue squamous cell carcinoma,Tregs,Tumor immunity,Tumor microenvironment

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Keywords: Bregs, CD40L, Double staining, IL-10, Immunosuppression, Oral oncology, Tongue squamous cell carcinoma, Tregs, Tumor immunity, Tumor microenvironment

CD19(+)IL-10(+) regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4(+) T cells to CD4(+)Foxp3(+) regulatory T cells.

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Abstract

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Regulatory T cell (Treg) therapy

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